Genetic control of tumor development in malformation syndromes

Floor A. M. Postema, Jan C. Oosterwijk, Raoul C. Hennekam*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

Samenvatting

One of the questions that arises frequently when caring for an individual with a malformation syndrome, is whether some form of tumor surveillance is indicated. In some syndromes there is a highly variable increased risk to develop tumors, while in others this is not the case. The risks can be hard to predict and difficult to explain to affected individuals and their families, and often also to caregivers. The queries arise especially if syndrome causing mutations are also known to occur in tumors. It needs insight in the mechanisms to understand and explain differences of tumor occurrence, and to offer optimal care to individuals with syndromes. Here we provide a short overview of the major mechanisms of the control for tumor occurrences in malformation syndromes.

Originele taal-2English
Pagina's (van-tot)1-12
Aantal pagina's12
TijdschriftAmerican Journal of Medical Genetics. Part A
Nummer van het tijdschrift2
DOI's
StatusPublished - 3-nov-2020

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