Genetic, parental and lifestyle factors influence telomere length

Sergio Andreu-Sánchez; Geraldine Aubert; Aida Ripoll-Cladellas; Sandra Henkelman; Daria V Zhernakova; Trishla Sinha; Alexander Kurilshikov; Maria Carmen Cenit; Marc Jan Bonder; Lude Franke; Cisca Wijmenga; Jingyuan Fu; Monique G P van der Wijst; Marta Melé; Peter Lansdorp; Alexandra Zhernakova

doi:10.1038/s42003-022-03521-7

Genetic, parental and lifestyle factors influence telomere length

Sergio Andreu-Sánchez^*, Geraldine Aubert, Aida Ripoll-Cladellas, Sandra Henkelman, Daria V Zhernakova, Trishla Sinha, Alexander Kurilshikov, Maria Carmen Cenit, Marc Jan Bonder, Lude Franke, Cisca Wijmenga, Jingyuan Fu, Monique G P van der Wijst, Marta Melé, Peter Lansdorp, Alexandra Zhernakova

^*Corresponding author voor dit werk

Onderzoeksoutput › Academic › peer review

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The average length of telomere repeats (TL) declines with age and is considered to be a marker of biological ageing. Here, we measured TL in six blood cell types from 1046 individuals using the clinically validated Flow-FISH method. We identified remarkable cell-type-specific variations in TL. Host genetics, environmental, parental and intrinsic factors such as sex, parental age, and smoking are associated to variations in TL. By analysing the genome-wide methylation patterns, we identified that the association of maternal, but not paternal, age to TL is mediated by epigenetics. Single-cell RNA-sequencing data for 62 participants revealed differential gene expression in T-cells. Genes negatively associated with TL were enriched for pathways related to translation and nonsense-mediated decay. Altogether, this study addresses cell-type-specific differences in telomere biology and its relation to cell-type-specific gene expression and highlights how perinatal factors play a role in determining TL, on top of genetics and lifestyle.

Originele taal-2	English
Artikelnummer	565
Aantal pagina's	13
Tijdschrift	Communications biology
Volume	5
Nummer van het tijdschrift	1
DOI's	https://doi.org/10.1038/s42003-022-03521-7
Status	Published - 9-jun.-2022

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Andreu-Sánchez, S., Aubert, G., Ripoll-Cladellas, A., Henkelman, S., Zhernakova, D. V., Sinha, T., Kurilshikov, A., Cenit, M. C., Jan Bonder, M., Franke, L., Wijmenga, C., Fu, J., van der Wijst, M. G. P., Melé, M., Lansdorp, P., & Zhernakova, A. (2022). Genetic, parental and lifestyle factors influence telomere length. Communications biology, 5(1), Artikel 565. https://doi.org/10.1038/s42003-022-03521-7

@article{4fca4689869f46228cd4c488d52ca1ef,

title = "Genetic, parental and lifestyle factors influence telomere length",

abstract = "The average length of telomere repeats (TL) declines with age and is considered to be a marker of biological ageing. Here, we measured TL in six blood cell types from 1046 individuals using the clinically validated Flow-FISH method. We identified remarkable cell-type-specific variations in TL. Host genetics, environmental, parental and intrinsic factors such as sex, parental age, and smoking are associated to variations in TL. By analysing the genome-wide methylation patterns, we identified that the association of maternal, but not paternal, age to TL is mediated by epigenetics. Single-cell RNA-sequencing data for 62 participants revealed differential gene expression in T-cells. Genes negatively associated with TL were enriched for pathways related to translation and nonsense-mediated decay. Altogether, this study addresses cell-type-specific differences in telomere biology and its relation to cell-type-specific gene expression and highlights how perinatal factors play a role in determining TL, on top of genetics and lifestyle.",

author = "Sergio Andreu-S{\'a}nchez and Geraldine Aubert and Aida Ripoll-Cladellas and Sandra Henkelman and Zhernakova, {Daria V} and Trishla Sinha and Alexander Kurilshikov and Cenit, {Maria Carmen} and {Jan Bonder}, Marc and Lude Franke and Cisca Wijmenga and Jingyuan Fu and {van der Wijst}, {Monique G P} and Marta Mel{\'e} and Peter Lansdorp and Alexandra Zhernakova",

note = "{\textcopyright} 2022. The Author(s).",

year = "2022",

month = jun,

day = "9",

doi = "10.1038/s42003-022-03521-7",

language = "English",

volume = "5",

journal = "Communications biology",

issn = "2399-3642",

publisher = "Nature Publishing Group",

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}

Andreu-Sánchez, S, Aubert, G, Ripoll-Cladellas, A, Henkelman, S, Zhernakova, DV, Sinha, T , Kurilshikov, A, Cenit, MC, Jan Bonder, M , Franke, L , Wijmenga, C , Fu, J , van der Wijst, MGP, Melé, M, Lansdorp, P & Zhernakova, A 2022, 'Genetic, parental and lifestyle factors influence telomere length', Communications biology, vol. 5, nr. 1, 565. https://doi.org/10.1038/s42003-022-03521-7

TY - JOUR

T1 - Genetic, parental and lifestyle factors influence telomere length

AU - Andreu-Sánchez, Sergio

AU - Aubert, Geraldine

AU - Ripoll-Cladellas, Aida

AU - Henkelman, Sandra

AU - Zhernakova, Daria V

AU - Sinha, Trishla

AU - Kurilshikov, Alexander

AU - Cenit, Maria Carmen

AU - Jan Bonder, Marc

AU - Franke, Lude

AU - Wijmenga, Cisca

AU - Fu, Jingyuan

AU - van der Wijst, Monique G P

AU - Melé, Marta

AU - Lansdorp, Peter

AU - Zhernakova, Alexandra

PY - 2022/6/9

Y1 - 2022/6/9

N2 - The average length of telomere repeats (TL) declines with age and is considered to be a marker of biological ageing. Here, we measured TL in six blood cell types from 1046 individuals using the clinically validated Flow-FISH method. We identified remarkable cell-type-specific variations in TL. Host genetics, environmental, parental and intrinsic factors such as sex, parental age, and smoking are associated to variations in TL. By analysing the genome-wide methylation patterns, we identified that the association of maternal, but not paternal, age to TL is mediated by epigenetics. Single-cell RNA-sequencing data for 62 participants revealed differential gene expression in T-cells. Genes negatively associated with TL were enriched for pathways related to translation and nonsense-mediated decay. Altogether, this study addresses cell-type-specific differences in telomere biology and its relation to cell-type-specific gene expression and highlights how perinatal factors play a role in determining TL, on top of genetics and lifestyle.

AB - The average length of telomere repeats (TL) declines with age and is considered to be a marker of biological ageing. Here, we measured TL in six blood cell types from 1046 individuals using the clinically validated Flow-FISH method. We identified remarkable cell-type-specific variations in TL. Host genetics, environmental, parental and intrinsic factors such as sex, parental age, and smoking are associated to variations in TL. By analysing the genome-wide methylation patterns, we identified that the association of maternal, but not paternal, age to TL is mediated by epigenetics. Single-cell RNA-sequencing data for 62 participants revealed differential gene expression in T-cells. Genes negatively associated with TL were enriched for pathways related to translation and nonsense-mediated decay. Altogether, this study addresses cell-type-specific differences in telomere biology and its relation to cell-type-specific gene expression and highlights how perinatal factors play a role in determining TL, on top of genetics and lifestyle.

U2 - 10.1038/s42003-022-03521-7

DO - 10.1038/s42003-022-03521-7

M3 - Article

C2 - 35681050

SN - 2399-3642

VL - 5

JO - Communications biology

JF - Communications biology

IS - 1

M1 - 565

ER -

Genetic, parental and lifestyle factors influence telomere length

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