Genetic screens in Caenorhabditis elegans models for neurodegenerative diseases

Olga Alvarenga Fernandes Sin; Helen Michels; Ellen A. A. Nollen

doi:10.1016/j.bbadis.2014.01.015

Genetic screens in Caenorhabditis elegans models for neurodegenerative diseases

Olga Alvarenga Fernandes Sin, Helen Michels, Ellen A. A. Nollen^*

^*Corresponding author voor dit werk

Onderzoeksoutput › peer review

50 Citaten (Scopus)

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Caenorhabditis elegans comprises unique features that make it an attractive model organism in diverse fields of biology. Genetic screens are powerful to identify genes and C. elegans can be customized to forward or reverse genetic screens and to establish gene function. These genetic screens can be applied to "humanized" models of C. elegans for neurodegenerative diseases, enabling for example the identification of genes involved in protein aggregation, one of the hallmarks of these diseases. In this review, we will describe the genetic screens employed in C. elegans and how these can be used to understand molecular processes involved in neurodegenerative and other human diseases. This article is part of a Special Issue entitled: From Genome to Function. (C) 2014 Elsevier B.V. All rights reserved.

Originele taal-2	English
Pagina's (van-tot)	1951-1959
Aantal pagina's	9
Tijdschrift	Biochimica et biophysica acta-Molecular basis of disease
Volume	1842
Nummer van het tijdschrift	10
DOI's	https://doi.org/10.1016/j.bbadis.2014.01.015
Status	Published - okt.-2014

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@article{65afdce077404cfa910e39d925447877,

title = "Genetic screens in Caenorhabditis elegans models for neurodegenerative diseases",

abstract = "Caenorhabditis elegans comprises unique features that make it an attractive model organism in diverse fields of biology. Genetic screens are powerful to identify genes and C. elegans can be customized to forward or reverse genetic screens and to establish gene function. These genetic screens can be applied to {"}humanized{"} models of C. elegans for neurodegenerative diseases, enabling for example the identification of genes involved in protein aggregation, one of the hallmarks of these diseases. In this review, we will describe the genetic screens employed in C. elegans and how these can be used to understand molecular processes involved in neurodegenerative and other human diseases. This article is part of a Special Issue entitled: From Genome to Function. (C) 2014 Elsevier B.V. All rights reserved.",

keywords = "Caenorhabditis elegans, Nematode, Genetic screen, RNAi, EMS, Neurodegenerative disease, Modifier gene, SYSTEMATIC RNAI SCREEN, BETA-AMYLOID PEPTIDE, PARKINSONS-DISEASE, ALPHA-SYNUCLEIN, ALZHEIMERS-DISEASE, C-ELEGANS, BODY FORMATION, CELL-DEATH, LIFE-SPAN, PROTEIN",

author = "{Alvarenga Fernandes Sin}, Olga and Helen Michels and Nollen, {Ellen A. A.}",

year = "2014",

month = oct,

doi = "10.1016/j.bbadis.2014.01.015",

language = "English",

volume = "1842",

pages = "1951--1959",

journal = "Biochimica et biophysica acta-Molecular basis of disease",

issn = "0925-4439",

publisher = "ELSEVIER SCIENCE BV",

number = "10",

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TY - JOUR

T1 - Genetic screens in Caenorhabditis elegans models for neurodegenerative diseases

AU - Alvarenga Fernandes Sin, Olga

AU - Michels, Helen

AU - Nollen, Ellen A. A.

PY - 2014/10

Y1 - 2014/10

N2 - Caenorhabditis elegans comprises unique features that make it an attractive model organism in diverse fields of biology. Genetic screens are powerful to identify genes and C. elegans can be customized to forward or reverse genetic screens and to establish gene function. These genetic screens can be applied to "humanized" models of C. elegans for neurodegenerative diseases, enabling for example the identification of genes involved in protein aggregation, one of the hallmarks of these diseases. In this review, we will describe the genetic screens employed in C. elegans and how these can be used to understand molecular processes involved in neurodegenerative and other human diseases. This article is part of a Special Issue entitled: From Genome to Function. (C) 2014 Elsevier B.V. All rights reserved.

AB - Caenorhabditis elegans comprises unique features that make it an attractive model organism in diverse fields of biology. Genetic screens are powerful to identify genes and C. elegans can be customized to forward or reverse genetic screens and to establish gene function. These genetic screens can be applied to "humanized" models of C. elegans for neurodegenerative diseases, enabling for example the identification of genes involved in protein aggregation, one of the hallmarks of these diseases. In this review, we will describe the genetic screens employed in C. elegans and how these can be used to understand molecular processes involved in neurodegenerative and other human diseases. This article is part of a Special Issue entitled: From Genome to Function. (C) 2014 Elsevier B.V. All rights reserved.

KW - Caenorhabditis elegans

KW - Nematode

KW - Genetic screen

KW - RNAi

KW - EMS

KW - Neurodegenerative disease

KW - Modifier gene

KW - SYSTEMATIC RNAI SCREEN

KW - BETA-AMYLOID PEPTIDE

KW - PARKINSONS-DISEASE

KW - ALPHA-SYNUCLEIN

KW - ALZHEIMERS-DISEASE

KW - C-ELEGANS

KW - BODY FORMATION

KW - CELL-DEATH

KW - LIFE-SPAN

KW - PROTEIN

U2 - 10.1016/j.bbadis.2014.01.015

DO - 10.1016/j.bbadis.2014.01.015

M3 - Review article

SN - 0925-4439

VL - 1842

SP - 1951

EP - 1959

JO - Biochimica et biophysica acta-Molecular basis of disease

JF - Biochimica et biophysica acta-Molecular basis of disease

IS - 10

ER -

Genetic screens in Caenorhabditis elegans models for neurodegenerative diseases

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