Genetically Determined High Levels of Iron Parameters Are Protective for Coronary Artery Disease

Niels Grote Beverborg, M Abdullah Said, Haye H van der Wal, Niek Verweij, Peter van der Meer, Pim van der Harst*

*Bijbehorende auteur voor dit werk

Onderzoeksoutput: LetterAcademicpeer review

Samenvatting

The observation that premenopausal women have a relatively low incidence of heart disease led in the nineteen eighties to the hypothesis that iron deficiency protects against heart diseases. These early observations were followed-up by conflicting epidemiological data. To confer causal relationships from epidemiological data is challenging as results can be influenced by residual confounding or reverse causation. For bias reduction, an alternative analysis strategy utilizing single-nucleotide polymorphisms (SNPs) as instrumental variables (Mendelian Randomization) has been developed. A recent study using 3 iron status associated SNPs suggested a protective effect of a higher iron status on the development of CAD.3 With a larger set of SNPs covering different components of iron metabolism, we aimed to provide a reliable answer to this lingering question.

Originele taal-2English
Artikelnummere002544
Pagina's (van-tot)36-38
Aantal pagina's3
TijdschriftCirculation. Genomic and precision medicine
Volume13
Nummer van het tijdschrift1
Vroegere onlinedatum12-jan-2020
DOI's
StatusPublished - feb-2020

Citeer dit