TY - JOUR
T1 - Genetics in heart failure
T2 - where are we headed?
AU - de Boer, Rudolf A.
AU - van den Berg, Maarten P.
AU - van Veldhuisen, Dirk J.
PY - 2006
Y1 - 2006
N2 - Heart failure is a complex disease with many precipitating factors. Novel insights into the genetic background of heart failure have boosted new areas of research that gave rise to the concept of genetic predisposition for heart failure. Various genetic defects and variances have been identified and subsequently linked to the onset of or progression to heart failure. Nevertheless, our understanding of the genetic basis for heart failure is incomplete because we lack knowledge of the functionality of genetic variances. We also do not understand the impact of genetic variances in noncoding DNA because of logistic problems in performing whole-genome scans and difficulties in statistical evaluation of large amounts of data generated by the genetic boom. It is expected that in the future we will be able to overcome these problems and apply the knowledge gained by genetic analyses to target and optimize treatment.
AB - Heart failure is a complex disease with many precipitating factors. Novel insights into the genetic background of heart failure have boosted new areas of research that gave rise to the concept of genetic predisposition for heart failure. Various genetic defects and variances have been identified and subsequently linked to the onset of or progression to heart failure. Nevertheless, our understanding of the genetic basis for heart failure is incomplete because we lack knowledge of the functionality of genetic variances. We also do not understand the impact of genetic variances in noncoding DNA because of logistic problems in performing whole-genome scans and difficulties in statistical evaluation of large amounts of data generated by the genetic boom. It is expected that in the future we will be able to overcome these problems and apply the knowledge gained by genetic analyses to target and optimize treatment.
UR - http://www.scopus.com/inward/record.url?scp=39049174367&partnerID=8YFLogxK
U2 - 10.1111/j.1527-5299.2006.05724.x
DO - 10.1111/j.1527-5299.2006.05724.x
M3 - Review article
C2 - 17170587
AN - SCOPUS:39049174367
SN - 1527-5299
VL - 12
SP - 329
EP - 332
JO - Congestive heart failure (Greenwich, Conn.)
JF - Congestive heart failure (Greenwich, Conn.)
IS - 6
ER -