GENETISCHE ASPECTEN BIJ HET METABOLISME VAN GENEESMIDDELEN: DE INTERINDIVIDUELE VERSCHILLEN VERDER ONTRAFELD

For many enzymes involved in drug metabolism different phenotypes have been discovered with a wide range of enzymatic activity. In this way, oxidation (by cytochrome P450), N-acetylation (by N-acetyltransferase), glucuronidation (by uridine glucuronosyl transferase), sulfation (by sulfotransferase) and thiopurine S-methylation (by thiopurine S-methyl transferase) have been studied extensively. This research has led to a better understanding of the metabolic processes in the human liver. Several polymorphisms and their clinical consequences are discussed.