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For many enzymes involved in drug metabolism different phenotypes have been discovered with a wide range of enzymatic activity. In this way, oxidation (by cytochrome P450), N-acetylation (by N-acetyltransferase), glucuronidation (by uridine glucuronosyl transferase), sulfation (by sulfotransferase) and thiopurine S-methylation (by thiopurine S-methyl transferase) have been studied extensively. This research has led to a better understanding of the metabolic processes in the human liver. Several polymorphisms and their clinical consequences are discussed.
Vertaalde titel van de bijdrageInterindividual differences disentangled. Genetic aspects of drug metabolism
Originele taal-2Dutch
Pagina's (van-tot)1679-1684
Aantal pagina's6
TijdschriftPharmaceutisch Weekblad
Nummer van het tijdschrift45
StatusPublished - 6-nov.-1998

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