Genome-Wide Epigenetic Perturbation Jump-Starts Patterns of Heritable Variation Found in Nature

Fabrice Roux; Maria Colomé-Tatché; Cécile Edelist; René Wardenaar; Philippe Guerche; Frédéric Hospital; Vincent Colot; Ritsert C. Jansen; Frank Johannes

doi:10.1534/genetics.111.128744

Genome-Wide Epigenetic Perturbation Jump-Starts Patterns of Heritable Variation Found in Nature

Fabrice Roux, Maria Colomé-Tatché, Cécile Edelist, René Wardenaar, Philippe Guerche, Frédéric Hospital, Vincent Colot, Ritsert C. Jansen, Frank Johannes^*

^*Corresponding author voor dit werk

Onderzoeksoutput › Academic › peer review

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We extensively phenotyped 6000 Arabidopsis plants with experimentally perturbed DNA methylomes as well as a diverse panel of natural accessions in a common garden. We found that alterations in DNA methylation not only caused heritable phenotypic diversity but also produced heritability patterns closely resembling those of the natural accessions. Our findings indicate that epigenetically induced and naturally occurring variation in complex traits share part of their polygenic architecture and may offer complementary adaptation routes in ecological settings.

Originele taal-2	English
Pagina's (van-tot)	1015-1017
Aantal pagina's	3
Tijdschrift	Genetics
Volume	188
Nummer van het tijdschrift	4
DOI's	https://doi.org/10.1534/genetics.111.128744
Status	Published - 2011

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Genome-Wide Epigenetic Perturbation Jump-StartsPatterns of Heritable Variation Found in Nature
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title = "Genome-Wide Epigenetic Perturbation Jump-Starts Patterns of Heritable Variation Found in Nature",

abstract = "We extensively phenotyped 6000 Arabidopsis plants with experimentally perturbed DNA methylomes as well as a diverse panel of natural accessions in a common garden. We found that alterations in DNA methylation not only caused heritable phenotypic diversity but also produced heritability patterns closely resembling those of the natural accessions. Our findings indicate that epigenetically induced and naturally occurring variation in complex traits share part of their polygenic architecture and may offer complementary adaptation routes in ecological settings.",

author = "Fabrice Roux and Maria Colom{\'e}-Tatch{\'e} and C{\'e}cile Edelist and Ren{\'e} Wardenaar and Philippe Guerche and Fr{\'e}d{\'e}ric Hospital and Vincent Colot and Jansen, {Ritsert C.} and Frank Johannes",

note = "Relation: http://www.rug.nl/gbb/ Rights: University of Groningen, Groningen Biomolecular Sciences and Biotechnology Institute",

year = "2011",

doi = "10.1534/genetics.111.128744",

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T1 - Genome-Wide Epigenetic Perturbation Jump-Starts Patterns of Heritable Variation Found in Nature

AU - Roux, Fabrice

AU - Colomé-Tatché, Maria

AU - Edelist, Cécile

AU - Wardenaar, René

AU - Guerche, Philippe

AU - Hospital, Frédéric

AU - Colot, Vincent

AU - Jansen, Ritsert C.

AU - Johannes, Frank

N1 - Relation: http://www.rug.nl/gbb/ Rights: University of Groningen, Groningen Biomolecular Sciences and Biotechnology Institute

PY - 2011

Y1 - 2011

N2 - We extensively phenotyped 6000 Arabidopsis plants with experimentally perturbed DNA methylomes as well as a diverse panel of natural accessions in a common garden. We found that alterations in DNA methylation not only caused heritable phenotypic diversity but also produced heritability patterns closely resembling those of the natural accessions. Our findings indicate that epigenetically induced and naturally occurring variation in complex traits share part of their polygenic architecture and may offer complementary adaptation routes in ecological settings.

AB - We extensively phenotyped 6000 Arabidopsis plants with experimentally perturbed DNA methylomes as well as a diverse panel of natural accessions in a common garden. We found that alterations in DNA methylation not only caused heritable phenotypic diversity but also produced heritability patterns closely resembling those of the natural accessions. Our findings indicate that epigenetically induced and naturally occurring variation in complex traits share part of their polygenic architecture and may offer complementary adaptation routes in ecological settings.

U2 - 10.1534/genetics.111.128744

DO - 10.1534/genetics.111.128744

M3 - Article

SN - 0016-6731

VL - 188

SP - 1015

EP - 1017

JO - Genetics

JF - Genetics

IS - 4

ER -

Genome-Wide Epigenetic Perturbation Jump-Starts Patterns of Heritable Variation Found in Nature

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