Global Leadership Initiative on Malnutrition (GLIM): Guidance on Validation of the Operational Criteria for the Diagnosis of Protein-Energy Malnutrition in Adults

GLIM Consortium, Heather Keller*, Marian A. E. de van der Schueren, Gordon L. Jensen, Rocco Barazzoni, Charlene Compher, M. Isabel T. D. Correia, M. Cristina Gonzalez, Harriet Jager-Wittenaar, Matthias Pirlich, Alison Steiber, Dan Waitzberg, Tommy Cederholm

*Bijbehorende auteur voor dit werk

    OnderzoeksoutputAcademicpeer review

    38 Citaten (Scopus)
    127 Downloads (Pure)


    Background The Global Leadership Initiative on Malnutrition (GLIM) created a consensus-based framework consisting of phenotypic and etiologic criteria to record the occurrence of malnutrition in adults. This is a minimum set of practicable indicators for use in characterizing a patient/client as malnourished, considering the global variations in screening and nutrition assessment, and to be used across different healthcare settings. As with other consensus-based frameworks for diagnosing disease states, these operational criteria require validation and reliability testing, as they are currently based solely on expert opinion. Methods Several forms of validation and reliability are reviewed in the context of GLIM, providing guidance on how to conduct retrospective and prospective studies for criterion and construct validity. Results There are some aspects of GLIM that require refinement; research using large databases can be employed to reach this goal. Machine learning is also introduced as a potential method to support identification of the best cut points and combinations of indicators for use with the different forms of malnutrition, which the GLIM criteria were created to denote. It is noted as well that validation and reliability testing need to occur in a variety of sectors and populations and with diverse persons using GLIM criteria. Conclusion The guidance presented supports the conduct and publication of quality validation and reliability studies for GLIM.

    Originele taal-2English
    Pagina's (van-tot)992-1003
    Aantal pagina's12
    TijdschriftJournal of Parenteral and Enteral Nutrition
    Nummer van het tijdschrift6
    StatusPublished - aug-2020

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