Global Network Reorganization During Dynamic Adaptations of Bacillus subtilis Metabolism

Joerg Martin Buescher, Wolfram Liebermeister, Matthieu Jules, Markus Uhr, Jan Muntel, Eric Botella, Bernd Hessling, Roelco Jacobus Kleijn, Ludovic Le Chat, Francois Lecointe, Ulrike Maeder, Pierre Nicolas, Sjouke Piersma, Frank Ruegheimer, Doerte Becher, Philippe Bessieres, Elena Bidnenko, Emma L. Denham, Etienne Dervyn, Kevin M. DevineGeoff Doherty, Samuel Drulhe, Liza Felicori, Mark J. Fogg, Anne Goelzer, Annette Hansen, Colin R. Harwood, Michael Hecker, Sebastian Hubner, Claus Hultschig, Hanne Jarmer, Edda Klipp, Aurelie Leduc, Peter Lewis, Frank Molina, Philippe Noirot, Sabine Peres, Nathalie Pigeonneau, Susanne Pohl, Simon Rasmussen, Bernd Rinn, Marc Schaffer, Julian Schnidder, Benno Schwikowski, Jan Maarten Van Dijl, Patrick Veiga, Sean Walsh, Anthony J. Wilkinson, Joerg Stelling*, Stephane Aymerich, Uwe Sauer

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

223 Citaten (Scopus)

Samenvatting

Adaptation of cells to environmental changes requires dynamic interactions between metabolic and regulatory networks, but studies typically address only one or a few layers of regulation. For nutritional shifts between two preferred carbon sources of Bacillus subtilis, we combined statistical and model-based data analyses of dynamic transcript, protein, and metabolite abundances and promoter activities. Adaptation to malate was rapid and primarily controlled posttranscriptionally compared with the slow, mainly transcriptionally controlled adaptation to glucose that entailed nearly half of the known transcription regulation network. Interactions across multiple levels of regulation were involved in adaptive changes that could also be achieved by controlling single genes. Our analysis suggests that global trade-offs and evolutionary constraints provide incentives to favor complex control programs.

Originele taal-2English
Pagina's (van-tot)1099-1103
Aantal pagina's5
TijdschriftScience
Volume335
Nummer van het tijdschrift6072
DOI's
StatusPublished - 2-mrt.-2012

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