Glucocorticosteroids Associated With a Decreased Risk of Psychosis

Wijnand Laan*, Hugo Smeets, Niek J. de Wit, Rene S. Kahn, Diederick E. Grobbee, Huibert Burger

*Corresponding author voor dit werk

OnderzoeksoutputAcademicpeer review

25 Citaten (Scopus)
376 Downloads (Pure)

Samenvatting

The hypothesis that chronic inflammation may play a role in psychosis receives increasing attention. In this study, we aim to investigate whether the use of steroidal anti-inflammatory drugs is associated with a decreased risk of psychosis.

A longitudinal nested case-control study was performed investigating the association of glucocorticosteroid (GCS) consumption with a new diagnosis of a psychotic disorder. Significantly reduced odds ratios of 0.52 (95% confidence interval, 0.36-0.75) were found for GCS in men only (odds ratio in women, 0.84 [95% confidence interval, 0.590-1.20]). Similar risk reductions were present for the inhaled and systemic GCSs. A dose-response relationship was present. Our finding of an inverse relation between GCS consumption and new psychotic episodes may promote further research into inflammation in schizophrenia.

Originele taal-2English
Pagina's (van-tot)288-290
Aantal pagina's3
TijdschriftJournal of Clinical Psychopharmacology
Volume29
Nummer van het tijdschrift3
DOI's
StatusPublished - jun.-2009

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