Glycans in autophagy, endocytosis and lysosomal functions

Fulvio Reggiori, Hans-Joachim Gabius, Massimo Aureli, Winfried Römer, Sandro Sonnino, Eeva-Liisa Eskelinen*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

4 Citaten (Scopus)
28 Downloads (Pure)

Samenvatting

Glycans have been shown to function as versatile molecular signals in cells. This prompted us to look at their roles in endocytosis, endolysosomal system and autophagy. We start by introducing the cell biological aspects of these pathways, the concept of the sugar code, and provide an overview on the role of glycans in the targeting of lysosomal proteins and in lysosomal functions. Moreover, we review evidence on the regulation of endocytosis and autophagy by glycans. Finally, we discuss the emerging concept that cytosolic exposure of luminal glycans, and their detection by endogenous lectins, provides a mechanism for the surveillance of the integrity of the endolysosomal compartments, and serves their eventual repair or disposal.

Originele taal-2English
Pagina's (van-tot)625-647
Aantal pagina's23
TijdschriftGlycoconjugate journal
Volume38
Nummer van het tijdschrift5
Vroegere onlinedatum14-aug-2021
DOI's
StatusPublished - okt-2021

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