Samenvatting
We describe a series of easily accessible, visible-light-sensitive (lambda > 500 nm) BODIPY (boron-dipyrromethene)based photoprotecting groups (PPGs) for primary and secondary amines, based on a carbamate linker. The caged compounds are stable under aqueous conditions for 24 h and can be efficiently uncaged in vitro with visible light (lambda = 530 nm). These properties allow efficient photodeprotection of amines, rendering these novel PPGs potentially suitable for various applications, including the delivery of caged drugs and their remote activation.
Originele taal-2 | English |
---|---|
Pagina's (van-tot) | 1819-1827 |
Aantal pagina's | 9 |
Tijdschrift | Journal of Organic Chemistry |
Volume | 83 |
Nummer van het tijdschrift | 4 |
DOI's | |
Status | Published - 16-feb.-2018 |