Green-Light-Sensitive BODIPY Photoprotecting Groups for Amines

Kaja Sitkowska, Ben. L. Feringa, Wiktor Szymanski*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

35 Citaten (Scopus)
323 Downloads (Pure)

Samenvatting

We describe a series of easily accessible, visible-light-sensitive (lambda > 500 nm) BODIPY (boron-dipyrromethene)based photoprotecting groups (PPGs) for primary and secondary amines, based on a carbamate linker. The caged compounds are stable under aqueous conditions for 24 h and can be efficiently uncaged in vitro with visible light (lambda = 530 nm). These properties allow efficient photodeprotection of amines, rendering these novel PPGs potentially suitable for various applications, including the delivery of caged drugs and their remote activation.

Originele taal-2English
Pagina's (van-tot)1819-1827
Aantal pagina's9
TijdschriftJournal of Organic Chemistry
Volume83
Nummer van het tijdschrift4
DOI's
StatusPublished - 16-feb-2018

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