Hair cell transducer channel properties and accuracy of cochlear signal-processing

C. J.W. Meulenberg*, S. M. van Netten

*Bijbehorende auteur voor dit werk

    OnderzoeksoutputAcademicpeer review

    Samenvatting

    Mechanically activated transducer channels in cochlear outer hair cells (OHC's) transduce sound encoded mechanical signals into electrical signals. Entry of extracellular Ca2+ through these channels modulates transduction by reducing their open probability, a phenomenon called adaptation [1]. Analysis of the mechanical and electrical characteristics of the transducer channels in OHC's has shown that the transducer channel's open probability can be adequately described by a differentially activating two-state model [2]. Also a direct relationship was demonstrated between the gating spring stiffness (K-s) and the accuracy (sigma(min) = 2kT/[K-s D] = 5.4 nm, where D is the distance between the engaging positions of the closed and open conformational state) with which hair bundle position can be detected as a result of intrinsic channel stochastics. In combination with an assumed Ca2+-dependent gating spring stiffness [e.g. 3], we predict on the basis of the two-state model that at endolymphatic Ca2+ concentrations (similar to 20 mu M) an improved accuracy (alpha(min) similar to 3 nm) can be attained at the equilibrium position of the hair bundle.

    Originele taal-2English
    TitelAuditory Mechanisms
    SubtitelProcesses and Models - Proceedings of the 9th International Symposium
    RedacteurenAlfred L. Nuttall, Tianying Ren, Peter Gillespie, Karl Grosh, Egbert de Boer
    Plaats van productieSINGAPORE
    UitgeverijWorld Scientific Publishing
    Pagina's293-294
    Aantal pagina's2
    ISBN van elektronische versie9812568247, 9789812568243
    ISBN van geprinte versie981-256-824-7
    DOI's
    StatusPublished - 2005
    Evenement9th International Mechanics of Hearing Workshop on Auditory Mechanisms: Processes and Models, MoH 2005 - Portland, United States
    Duur: 23-jul.-200528-jul.-2005

    Publicatie series

    NaamAuditory Mechanisms: Processes and Models - Proceedings of the 9th International Symposium

    Conference

    Conference9th International Mechanics of Hearing Workshop on Auditory Mechanisms: Processes and Models, MoH 2005
    Land/RegioUnited States
    StadPortland
    Periode23/07/200528/07/2005

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