TY - JOUR
T1 - Hallmarks of Cellular Senescence
AU - Hernandez-Segura, Alejandra
AU - Nehme, Jamil
AU - Demaria, Marco
N1 - Copyright © 2018 Elsevier Ltd. All rights reserved.
PY - 2018/6
Y1 - 2018/6
N2 - Cellular senescence is a permanent state of cell cycle arrest that promotes tissue remodeling during development and after injury, but can also contribute to the decline of the regenerative potential and function of tissues, to inflammation, and to tumorigenesis in aged organisms. Therefore, the identification, characterization, and pharmacological elimination of senescent cells have gained attention in the field of aging research. However, the nonspecificity of current senescence markers and the existence of different senescence programs strongly limit these tasks. Here, we describe the molecular regulators of senescence phenotypes and how they are used for identifying senescent cells in vitro and in vivo. We also highlight the importance that these levels of regulations have in the development of therapeutic targets.
AB - Cellular senescence is a permanent state of cell cycle arrest that promotes tissue remodeling during development and after injury, but can also contribute to the decline of the regenerative potential and function of tissues, to inflammation, and to tumorigenesis in aged organisms. Therefore, the identification, characterization, and pharmacological elimination of senescent cells have gained attention in the field of aging research. However, the nonspecificity of current senescence markers and the existence of different senescence programs strongly limit these tasks. Here, we describe the molecular regulators of senescence phenotypes and how they are used for identifying senescent cells in vitro and in vivo. We also highlight the importance that these levels of regulations have in the development of therapeutic targets.
KW - ONCOGENE-INDUCED SENESCENCE
KW - DNA-DAMAGE RESPONSE
KW - LYSOSOMAL BETA-GALACTOSIDASE
KW - HUMAN-DIPLOID FIBROBLASTS
KW - TUMOR-SUPPRESSOR GENE
KW - SECRETORY PHENOTYPE
KW - OXIDATIVE STRESS
KW - MITOCHONDRIAL DYSFUNCTION
KW - PREMATURE SENESCENCE
KW - TRANSCRIPTIONAL REGULATION
U2 - 10.1016/j.tcb.2018.02.001
DO - 10.1016/j.tcb.2018.02.001
M3 - Review article
C2 - 29477613
SN - 0962-8924
VL - 28
SP - 436
EP - 453
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 6
ER -