Hallmarks of Cellular Senescence

Alejandra Hernandez-Segura, Jamil Nehme, Marco Demaria*

*Corresponding author voor dit werk

    Onderzoeksoutput: Review articlepeer review

    1808 Citaten (Scopus)
    3947 Downloads (Pure)

    Samenvatting

    Cellular senescence is a permanent state of cell cycle arrest that promotes tissue remodeling during development and after injury, but can also contribute to the decline of the regenerative potential and function of tissues, to inflammation, and to tumorigenesis in aged organisms. Therefore, the identification, characterization, and pharmacological elimination of senescent cells have gained attention in the field of aging research. However, the nonspecificity of current senescence markers and the existence of different senescence programs strongly limit these tasks. Here, we describe the molecular regulators of senescence phenotypes and how they are used for identifying senescent cells in vitro and in vivo. We also highlight the importance that these levels of regulations have in the development of therapeutic targets.

    Originele taal-2English
    Pagina's (van-tot)436-453
    Aantal pagina's18
    TijdschriftTrends in Cell Biology
    Volume28
    Nummer van het tijdschrift6
    Vroegere onlinedatum21-feb.-2018
    DOI's
    StatusPublished - jun.-2018

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