TY - JOUR
T1 - Harmony in the Molecular Orchestra of Hearing
T2 - Developmental Mechanisms from the Ear to the Brain
AU - Pyott, Sonja J.
AU - Pavlinkova, Gabriela
AU - Yamoah, Ebenezer N.
AU - Fritzsch, Bernd
N1 - Publisher Copyright:
© 2024 by the author(s).
PY - 2024/8/8
Y1 - 2024/8/8
N2 - Auditory processing in mammals begins in the peripheral inner ear and extends to the auditory cortex. Sound is transduced from mechanical stimuli into electrochemical signals of hair cells, which relay auditory information via the primary auditory neurons to cochlear nuclei. Information is subsequently processed in the superior olivary complex, lateral lemniscus, and inferior colliculus and projects to the auditory cortex via the medial geniculate body in the thalamus. Recent advances have provided valuable insights into the development and functioning of auditory structures, complementing our understanding of the physiological mechanisms underlying auditory processing. This comprehensive review explores the genetic mechanisms required for auditory system development from the peripheral cochlea to the auditory cortex. We highlight transcription factors and other genes with key recurring and interacting roles in guiding auditory system development and organization. Understanding these gene regulatory networks holds promise for developing novel therapeutic strategies for hearing disorders, benefiting millions globally.
AB - Auditory processing in mammals begins in the peripheral inner ear and extends to the auditory cortex. Sound is transduced from mechanical stimuli into electrochemical signals of hair cells, which relay auditory information via the primary auditory neurons to cochlear nuclei. Information is subsequently processed in the superior olivary complex, lateral lemniscus, and inferior colliculus and projects to the auditory cortex via the medial geniculate body in the thalamus. Recent advances have provided valuable insights into the development and functioning of auditory structures, complementing our understanding of the physiological mechanisms underlying auditory processing. This comprehensive review explores the genetic mechanisms required for auditory system development from the peripheral cochlea to the auditory cortex. We highlight transcription factors and other genes with key recurring and interacting roles in guiding auditory system development and organization. Understanding these gene regulatory networks holds promise for developing novel therapeutic strategies for hearing disorders, benefiting millions globally.
KW - auditory cortex
KW - cochlea
KW - cochlear nucleus
KW - inferior colliculus
KW - medial geniculate body
KW - superior olivary complex
UR - http://www.scopus.com/inward/record.url?scp=85197356232&partnerID=8YFLogxK
U2 - 10.1146/annurev-neuro-081423-093942
DO - 10.1146/annurev-neuro-081423-093942
M3 - Review article
C2 - 38360566
AN - SCOPUS:85197356232
SN - 0147-006X
VL - 47
SP - 1
EP - 20
JO - Annual Review of Neuroscience
JF - Annual Review of Neuroscience
ER -