HDL Particle Subspecies and Their Association With Incident Type 2 Diabetes: The PREVEND Study

Sara Sokooti*, Jose L Flores-Guerrero, Lyanne M Kieneker, Hiddo J L Heerspink, Margery A Connelly, Stephan J L Bakker, Robin P F Dullaart

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

2 Citaten (Scopus)
6 Downloads (Pure)


Context: High-density lipoproteins (HDL) may be protective against type 2 diabetes (T2D) development, but HDL particles vary in size and function, which could lead to differential associations with incident T2D. A newly developed nuclear magnetic resonance (NMR)derived algorithm provides concentrations for 7 HDL subspecies.

Objective: We aimed to investigate the association of HDL particle subspecies with incident T2D in the general population.

Methods: Among 4828 subjects of the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study without T2D at baseline, HDL subspecies with increasing size from H1P to H7P were measured by NMR (LP4 algorithm of the Vantera NMR platform).

Results: A total of 265 individuals developed T2D (median follow-up of 7.3 years). In Cox regression models, HDL size and H4P (hazard ratio [HR] per 1 SD increase 0.83 [95% CI, 0.690.99] and 0.85 [95% CI, 0.75-0.95], respectively) were inversely associated with incident T2D, after adjustment for relevant covariates. In contrast, levels of H2P were positively associated with incidentT2D (HR 1.15 [95% CI, 1.01-1.32]). In secondary analyses, associations with large HDL particles and H6P were modified by body mass index (BMI) in such a way that they were particularly associated with a lower risk of incident T2D, in subjects with BMI < 30 kg/m(2).

Conclusion: Greater HDL size and lower levels of H4P were associated with a lower risk, whereas higher levels of H2P were associated with a higher risk of developing T2D. In addition, large HDL particles and H6P were inversely associated with T2D in nonobese subjects.

Originele taal-2English
Pagina's (van-tot)1761-1772
Aantal pagina's12
TijdschriftJournal of Clinical Endocrinology and Metabolism
Nummer van het tijdschrift6
Vroegere onlinedatum10-feb-2021
StatusPublished - jun-2021

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