HE4 Serum Levels Are Associated with Heart Failure Severity in Patients With Chronic Heart Failure

Arnold Piek; Wouter C. Meijers; Nicolas F. Schroten; Ron T. Gansevoort; Rudolf A. de Boer; Herman H. W. Sillje

doi:10.1016/j.cardfail.2016.05.002

HE4 Serum Levels Are Associated with Heart Failure Severity in Patients With Chronic Heart Failure

Arnold Piek, Wouter C. Meijers, Nicolas F. Schroten, Ron T. Gansevoort, Rudolf A. de Boer, Herman H. W. Sillje^*

^*Corresponding author voor dit werk

Onderzoeksoutput: Article › Academic › peer review

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Background: The novel biomarker human epididymis protein 4 (HE4) shows prognostic value in acute heart failure (HF) patients. We measured HE4 levels in patients with chronic heart failure (CHF) and correlated them to HF severity, kidney function, and HF biomarkers, and determined its predictive value.

Methods: Serum HE4 levels in patients (n = 101) with stable CHF with reduced left ventricular ejection fraction (LVEF

Results: HE4 levels were higher in CHF compared with control subjects (69.2 pmol/L [interquartile range 55.6-93.8] vs 56.1 pmol/L [46.6-69.0]; P

Conclusions: HE4 levels are increased in CHF, correlate with HF severity and kidney function, and predict HF outcome.

Originele taal-2	English
Pagina's (van-tot)	12-19
Aantal pagina's	8
Tijdschrift	Journal of Cardiac Failure
Volume	23
Nummer van het tijdschrift	1
DOI's	https://doi.org/10.1016/j.cardfail.2016.05.002
Status	Published - jan.-2017

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10.1016/j.cardfail.2016.05.002Licentie: CC BY

HE4 Serum Levels Are Associated with Heart Failure SeverityFinal publisher's version, 369 KBLicentie: CC BY

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@article{5638e6757ae142fea80a1c5c5a75fa3a,

title = "HE4 Serum Levels Are Associated with Heart Failure Severity in Patients With Chronic Heart Failure",

abstract = "Background: The novel biomarker human epididymis protein 4 (HE4) shows prognostic value in acute heart failure (HF) patients. We measured HE4 levels in patients with chronic heart failure (CHF) and correlated them to HF severity, kidney function, and HF biomarkers, and determined its predictive value.Methods: Serum HE4 levels in patients (n = 101) with stable CHF with reduced left ventricular ejection fraction (LVEFResults: HE4 levels were higher in CHF compared with control subjects (69.2 pmol/L [interquartile range 55.6-93.8] vs 56.1 pmol/L [46.6-69.0]; PConclusions: HE4 levels are increased in CHF, correlate with HF severity and kidney function, and predict HF outcome.",

keywords = "HE4, WFDC2, chronic heart failure, fibrosis, EPIDIDYMIS PROTEIN 4, TASK-FORCE, GUIDELINES, PROGNOSIS, DIAGNOSIS, BIOMARKER",

author = "Arnold Piek and Meijers, {Wouter C.} and Schroten, {Nicolas F.} and Gansevoort, {Ron T.} and {de Boer}, {Rudolf A.} and Sillje, {Herman H. W.}",

year = "2017",

month = jan,

doi = "10.1016/j.cardfail.2016.05.002",

language = "English",

volume = "23",

pages = "12--19",

journal = "Journal of Cardiac Failure",

issn = "1071-9164",

publisher = "Churchill Livingstone",

number = "1",

}

TY - JOUR

T1 - HE4 Serum Levels Are Associated with Heart Failure Severity in Patients With Chronic Heart Failure

AU - Piek, Arnold

AU - Meijers, Wouter C.

AU - Schroten, Nicolas F.

AU - Gansevoort, Ron T.

AU - de Boer, Rudolf A.

AU - Sillje, Herman H. W.

PY - 2017/1

Y1 - 2017/1

N2 - Background: The novel biomarker human epididymis protein 4 (HE4) shows prognostic value in acute heart failure (HF) patients. We measured HE4 levels in patients with chronic heart failure (CHF) and correlated them to HF severity, kidney function, and HF biomarkers, and determined its predictive value.Methods: Serum HE4 levels in patients (n = 101) with stable CHF with reduced left ventricular ejection fraction (LVEFResults: HE4 levels were higher in CHF compared with control subjects (69.2 pmol/L [interquartile range 55.6-93.8] vs 56.1 pmol/L [46.6-69.0]; PConclusions: HE4 levels are increased in CHF, correlate with HF severity and kidney function, and predict HF outcome.

AB - Background: The novel biomarker human epididymis protein 4 (HE4) shows prognostic value in acute heart failure (HF) patients. We measured HE4 levels in patients with chronic heart failure (CHF) and correlated them to HF severity, kidney function, and HF biomarkers, and determined its predictive value.Methods: Serum HE4 levels in patients (n = 101) with stable CHF with reduced left ventricular ejection fraction (LVEFResults: HE4 levels were higher in CHF compared with control subjects (69.2 pmol/L [interquartile range 55.6-93.8] vs 56.1 pmol/L [46.6-69.0]; PConclusions: HE4 levels are increased in CHF, correlate with HF severity and kidney function, and predict HF outcome.

KW - HE4

KW - WFDC2

KW - chronic heart failure

KW - fibrosis

KW - EPIDIDYMIS PROTEIN 4

KW - TASK-FORCE

KW - GUIDELINES

KW - PROGNOSIS

KW - DIAGNOSIS

KW - BIOMARKER

U2 - 10.1016/j.cardfail.2016.05.002

DO - 10.1016/j.cardfail.2016.05.002

M3 - Article

SN - 1071-9164

VL - 23

SP - 12

EP - 19

JO - Journal of Cardiac Failure

JF - Journal of Cardiac Failure

IS - 1

ER -

HE4 Serum Levels Are Associated with Heart Failure Severity in Patients With Chronic Heart Failure

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