Hepato-biliary clinical trials and their inclusion in the Cochrane Hepato-Biliary Group register and reviews

Sarah Louise Klingenberg*, Dimitrinka Nikolova, Nicholas Alexakis, Bodil Als-Nielsen, Agostino Colli, Dario Conte, Gennaro D'Amico, Brian Davidson, Abe Fingerhut, Mirella Fraquelli, Lise Lotte Gluud, Kurinchi Gurusamy, Frederik Keus, Saboor Khan, Ronald Koretz, Cornelis van Laarhoven, Jianping Liu, Robert Myers, Luigi Pagliaro, Rosa SimonettiRobert Sutton, Kristian Thorlund, Christian Gluud

*Bijbehorende auteur voor dit werk

Onderzoeksoutput: Review articlepeer review

3 Citaten (Scopus)


Background and Aims:

The Cochrane Hepato-Biliary Group (CHBG) is one of the 52 collaborative review groups within The Cochrane Collaboration. The activities of the CHBG focus on collecting hepato-biliary randomized clinical trials (RCT) and controlled clinical trials (CCT), and including them in systematic reviews with meta-analyses of the trials. In this overview, we present the growth of The CHBG Controlled Trials Register, as well as the systematic reviews that have been produced since March 1996.


The CHBG register includes almost 11 000 RCT and 700 CCT publications. The earliest RCT in the register were published in 1955, and the earliest CCT in 1945. From 1945 to 1980, there were less than 100 publications each year. From 1981 to 1997, their number increased from over 100 to 600 a year. After 1997, the number of publications seems to have been decreasing. The CHBG has published 199 protocols for systematic reviews and 107 systematic reviews through to August 2009 in which 21% of the RCT and CCT were included. The CHBG reviews have been cited approximately 1200 times.


A large amount of work has been carried out since 1996. However, there is still much to do, as the CHBG register contains a great number of RCT and CCT on topics that have not yet been systematically reviewed.

Originele taal-2English
Pagina's (van-tot)649-656
Aantal pagina's8
TijdschriftJournal of gastroenterology and hepatology
Nummer van het tijdschrift4
StatusPublished - apr.-2011
Extern gepubliceerdJa

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