@article{af59d13e7f0d4b38bfb4d53e1d47e711,
title = "Heritability estimates for 361 blood metabolites across 40 genome-wide association studies",
abstract = "Metabolomics examines the small molecules involved in cellular metabolism. Approximately 50% of total phenotypic differences in metabolite levels is due to genetic variance, but heritability estimates differ across metabolite classes. We perform a review of all genome-wide association and (exome-) sequencing studies published between November 2008 and October 2018, and identify >800 class-specific metabolite loci associated with metabolite levels. In a twin-family cohort (N = 5117), these metabolite loci are leveraged to simultaneously estimate total heritability (h2 total), and the proportion of heritability captured by known metabolite loci (h2 Metabolite-hits) for 309 lipids and 52 organic acids. Our study reveals significant differences in h2 Metabolite-hits among different classes of lipids and organic acids. Furthermore, phosphatidylcholines with a high degree of unsaturation have higher h2 Metabolite-hits estimates than phosphatidylcholines with low degrees of unsaturation. This study highlights the importance of common genetic variants for metabolite levels, and elucidates the genetic architecture of metabolite classes.",
keywords = "NETHERLANDS TWIN REGISTER, MISSING HERITABILITY, GENOTYPE IMPUTATION, VARIANCE-ESTIMATION, METABOLOMICS, SELECTION, DATABASE, BIOBANK",
author = "{BBMRI Metabolomics Consortium} and Hagenbeek, {Fiona A.} and Rene Pool and {van Dongen}, Jenny and Draisma, {Harmen H. M.} and {Jan Hottenga}, Jouke and Gonneke Willemsen and Abdel Abdellaoui and Fedko, {Iryna O.} and {den Braber}, Anouk and Visser, {Pieter Jelle} and {de Geus}, {Eco J. C. N.} and {Willems van Dijk}, Ko and Aswin Verhoeven and Suchiman, {H. Eka} and Marian Beekman and Slagboom, {P. Eline} and {van Duijn}, {Cornelia M.} and Harms, {Amy C.} and Thomas Hankemeier and Meike Bartels and Nivard, {Michel G.} and Boomsma, {Dorret I.} and Wolf, {J. J. H. Barkey} and D. Cats and N. Amin and Beulens, {J. W.} and {van der Bom}, {J. A.} and N. Bomer and A. Demirkan and {van Hilten}, {J. A.} and Meessen, {J. M. T. A.} and Moed, {M. H.} and J. Fu and Onderwater, {G. L. J.} and F. Rutters and Asselbergs, {F. W.} and E. Boersma and Geleijnse, {J. M.} and Penninx, {B. W. J. H.} and Stehouwer, {C. D. A.} and Teunissen, {C. E.} and {'t Hart}, {L. M.} and {van der Harst}, P. and {van der Horst}, {I. C. C.} and C. Wijmenga and H. Mei and M. Slofstra and M. Swertz and J. Deelen and Reinders, {M. J. T.}",
year = "2020",
month = jan,
day = "7",
doi = "10.1038/s41467-019-13770-6",
language = "English",
volume = "11",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",
}