HIFs, angiogenesis, and metabolism: elusive enemies in breast cancer

Ellen C de Heer, Mathilde Jalving, Adrian L Harris*

*Corresponding author voor dit werk

    Onderzoeksoutputpeer review

    246 Citaten (Scopus)
    296 Downloads (Pure)

    Samenvatting

    Hypoxia-inducible factors (HIFs) and the HIF-dependent cancer hallmarks angiogenesis and metabolic rewiring are well-established drivers of breast cancer aggressiveness, therapy resistance, and poor prognosis. Targeting of HIF and its downstream targets in angiogenesis and metabolism has been unsuccessful so far in the breast cancer clinical setting, with major unresolved challenges residing in target selection, development of robust biomarkers for response prediction, and understanding and harnessing of escape mechanisms. This Review discusses the pathophysiological role of HIFs, angiogenesis, and metabolism in breast cancer and the challenges of targeting these features in patients with breast cancer. Rational therapeutic combinations, especially with immunotherapy and endocrine therapy, seem most promising in the clinical exploitation of the intricate interplay of HIFs, angiogenesis, and metabolism in breast cancer cells and the tumor microenvironment.

    Originele taal-2English
    Pagina's (van-tot)5074-5087
    Aantal pagina's14
    TijdschriftThe Journal of Clinical Investigation
    Volume130
    Nummer van het tijdschrift10
    Vroegere onlinedatum1-sep.-2020
    DOI's
    StatusPublished - 1-okt.-2020

    Vingerafdruk

    Duik in de onderzoeksthema's van 'HIFs, angiogenesis, and metabolism: elusive enemies in breast cancer'. Samen vormen ze een unieke vingerafdruk.

    Citeer dit