High burden of drug therapy in adult congenital heart disease: polypharmacy as marker of morbidity and mortality

Odilia Woudstra, Joey M. Kuijpers, Folkert J. Meijboom, Marco C. Post, Monique R. M. Jongbloed, Anthonie L. Duijnhouwer, Arie P. J. van Dijk, Joost P. van Melle, Thelma C. Konings, Aeilko H. Zwinderman, Barbara J. M. Mulder, Bert J. Bouma*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

7 Citaten (Scopus)
104 Downloads (Pure)


Aims To assess medication use in adult congenital heart disease (ACHD) patients compared to the age- and sex-matched general population, identify patterns of pharmacotherapy, and analyse associations between pharmacotherapy and adverse outcomes in ACHD.

Methods and results Data of 14 138 ACHD patients from the CONCOR registry [35 (24-48) years, 49% male] and age- and sex-matched referents (1:10 ratio) were extracted from the Dutch Dispensed Drug Register for the years 2006-14. Adult congenital heart disease patients had more cardiovascular and non-cardiovascular drugs than referents (median 3 vs. 1, P= 5 dispensed drug types yearly, was present in 30% of ACHD and 15% of referents {odds ratio [OR]=2.47 [95% confidence interval (CI) 2.39-2.54]}. Polypharmacy was independently associated with female sex [OR=1.92 (95% CI 1.88-1.96)], older age [for men: OR=2.3/10years (95% CI 2.2-2.4) and for women: OR=1.6/10years (95% CI 1.5-1.6); P-interaction

Conclusion Both cardiovascular and non-cardiovascular medication use is high in ACHD with twice as much polypharmacy compared with the matched general population. Patients with polypharmacy had a four-fold increased risk of mortality and adverse drug events. Recognition of distinct medication patterns can help identify patients at highest risk. Drug regimens need repeating evaluation to assess the appropriateness of all prescriptions. More high-quality studies are needed to improve ACHD care with more evidence-based pharmacotherapy.

Originele taal-2English
Pagina's (van-tot)216-225
Aantal pagina's10
TijdschriftEuropean heart journal-Cardiovascular pharmacotherapy
Nummer van het tijdschrift4
StatusPublished - okt.-2019

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