Higher cortisol awakening response in young adolescents with persistent anxiety problems

K. Greaves-Lord, R. F. Ferdinand*, A. J. Oldehinkel, F. E. P. L. Sondeijker, J. Ormel, F. C. Verhulst

*Corresponding author voor dit werk

    Onderzoeksoutput: ArticleAcademicpeer review

    116 Citaten (Scopus)
    280 Downloads (Pure)

    Samenvatting

    Objective: The aims of the present study were to test the association between current anxiety problems and basal cortisol levels in a large population sample of young preadolescents, and to test if HPA-axis activity differs between individuals with no, only current, or persistent anxiety problems.

    Method: Cortisol levels of 10- to 12-year olds (n = 1768) from the general population were measured on three time points during the day. A self-report questionnaire (RCADS) was used to assess current anxiety, a parent-report questionnaire (TPBQ) to assess anxiety problems at age 4.

    Results: Associations between cortisol levels and current anxiety problems were not found. However, individuals with persistent anxiety problems had higher morning cortisol levels and a higher cortisol awakening response.

    Conclusion: Apparently, only persistent, and not current, anxiety problems are associated with higher HPA-axis activity. Alterations in HPA-axis activity might underlie persistent anxiety problems, or result from the stress accompanied by persistent anxiety problems.

    Originele taal-2English
    Pagina's (van-tot)137-144
    Aantal pagina's8
    TijdschriftActa Psychiatrica Scandinavica
    Volume116
    Nummer van het tijdschrift2
    DOI's
    StatusPublished - aug.-2007

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