Histone variants and lipid metabolism

Michela Borghesan, Gianluigi Mazzoccoli, Fareeba Sheedfar, Jude Oben, Valerio Pazienza*, Manlio Vinciguerra

*Bijbehorende auteur voor dit werk

    OnderzoeksoutputAcademicpeer review

    10 Citaten (Scopus)

    Samenvatting

    Within nucleosomes, canonical histones package the genome, but they can be opportunely replaced with histone variants. The incorporation of histone variants into the nucleosome is a chief cellular strategy to regulate transcription and cellular metabolism. In pathological terms, cellular steatosis is an abnormal accumulation of lipids, which reflects impairment in the turnover of triacylglycerols, affecting any organ but mainly the liver. The present review aims to summarize the experimental evidence for histone variant functions in lipid metabolism.

    Originele taal-2English
    Pagina's (van-tot)1409-1413
    Aantal pagina's5
    TijdschriftBiochemical Society Transactions
    Volume42
    DOI's
    StatusPublished - okt-2014

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