Histone variants and lipid metabolism

Michela Borghesan; Gianluigi Mazzoccoli; Fareeba Sheedfar; Jude Oben; Valerio Pazienza; Manlio Vinciguerra

doi:10.1042/BST20140119

Histone variants and lipid metabolism

Michela Borghesan
, Gianluigi Mazzoccoli
, Fareeba Sheedfar
, Jude Oben
, Valerio Pazienza^*
, Manlio Vinciguerra

^*Corresponding author voor dit werk

Onderzoeksoutput › Academic › peer review

13 Citaten (Scopus)

Samenvatting

Within nucleosomes, canonical histones package the genome, but they can be opportunely replaced with histone variants. The incorporation of histone variants into the nucleosome is a chief cellular strategy to regulate transcription and cellular metabolism. In pathological terms, cellular steatosis is an abnormal accumulation of lipids, which reflects impairment in the turnover of triacylglycerols, affecting any organ but mainly the liver. The present review aims to summarize the experimental evidence for histone variant functions in lipid metabolism.

Originele taal-2	English
Pagina's (van-tot)	1409-1413
Aantal pagina's	5
Tijdschrift	Biochemical Society Transactions
Volume	42
DOI's	https://doi.org/10.1042/BST20140119
Status	Published - okt.-2014

Toegang tot document

10.1042/BST20140119

Handle.net

Permanente koppeling

Citeer dit

@article{65d6970596da47f187e44657dc2efcab,

title = "Histone variants and lipid metabolism",

abstract = "Within nucleosomes, canonical histones package the genome, but they can be opportunely replaced with histone variants. The incorporation of histone variants into the nucleosome is a chief cellular strategy to regulate transcription and cellular metabolism. In pathological terms, cellular steatosis is an abnormal accumulation of lipids, which reflects impairment in the turnover of triacylglycerols, affecting any organ but mainly the liver. The present review aims to summarize the experimental evidence for histone variant functions in lipid metabolism.",

keywords = "gene expression, histone variant, lipid metabolism, nucleosome, steatosis, FATTY LIVER-DISEASE, HEPATIC STEATOSIS, MATERNAL OBESITY, CHROMATIN, GENOME, MICE, H3.3, EPIGENETICS, MACROH2A1, BINDING",

author = "Michela Borghesan and Gianluigi Mazzoccoli and Fareeba Sheedfar and Jude Oben and Valerio Pazienza and Manlio Vinciguerra",

year = "2014",

month = oct,

doi = "10.1042/BST20140119",

language = "English",

volume = "42",

pages = "1409--1413",

journal = "Biochemical Society Transactions",

issn = "0300-5127",

publisher = "PORTLAND PRESS LTD",

}

TY - JOUR

T1 - Histone variants and lipid metabolism

AU - Borghesan, Michela

AU - Mazzoccoli, Gianluigi

AU - Sheedfar, Fareeba

AU - Oben, Jude

AU - Pazienza, Valerio

AU - Vinciguerra, Manlio

PY - 2014/10

Y1 - 2014/10

N2 - Within nucleosomes, canonical histones package the genome, but they can be opportunely replaced with histone variants. The incorporation of histone variants into the nucleosome is a chief cellular strategy to regulate transcription and cellular metabolism. In pathological terms, cellular steatosis is an abnormal accumulation of lipids, which reflects impairment in the turnover of triacylglycerols, affecting any organ but mainly the liver. The present review aims to summarize the experimental evidence for histone variant functions in lipid metabolism.

AB - Within nucleosomes, canonical histones package the genome, but they can be opportunely replaced with histone variants. The incorporation of histone variants into the nucleosome is a chief cellular strategy to regulate transcription and cellular metabolism. In pathological terms, cellular steatosis is an abnormal accumulation of lipids, which reflects impairment in the turnover of triacylglycerols, affecting any organ but mainly the liver. The present review aims to summarize the experimental evidence for histone variant functions in lipid metabolism.

KW - gene expression

KW - histone variant

KW - lipid metabolism

KW - nucleosome

KW - steatosis

KW - FATTY LIVER-DISEASE

KW - HEPATIC STEATOSIS

KW - MATERNAL OBESITY

KW - CHROMATIN

KW - GENOME

KW - MICE

KW - H3.3

KW - EPIGENETICS

KW - MACROH2A1

KW - BINDING

U2 - 10.1042/BST20140119

DO - 10.1042/BST20140119

M3 - Article

SN - 0300-5127

VL - 42

SP - 1409

EP - 1413

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

ER -

Histone variants and lipid metabolism

Samenvatting

Toegang tot document

Handle.net

Vingerafdruk

Citeer dit