HLA class II alleles of susceptibility and protection in Brazilian and Dutch pemphigus foliaceus

L de Sena Nogueira Maehara, F C De-Souza-Santana, A M Porro, E V C Marcos, S Ura, I M Nolte, H H Pas, M F Jonkman, J Tomimori

OnderzoeksoutputAcademicpeer review

7 Citaten (Scopus)

Samenvatting

Pemphigus foliaceus (PF) is a worldwide chronic autoimmune bullous disease targeting desmoglein 1 (Dsg 1) on epithelial cell surface of skin and mucous membranes, causing lesions in skin but sparing mucosa, since the latter contain compensating desmoglein 3(1) . Several environmental triggers for the autoimmune reaction have been imputed, such as drugs, ultraviolet radiation and mercurium. Human leucocyte antigens class II (HLA-DR4) alleles were linked to the disease in Ashkenazi Jews and other populations(2) . For endemic pemphigus foliaceus in Brazil, named fogo selvagem (FS), HLA-DRB1*04 was shown to have a relative risk >14 for the disease(3) . This article is protected by copyright. All rights reserved.

Originele taal-2English
Pagina's (van-tot)e212-e214
Aantal pagina's3
TijdschriftThe British journal of dermatology
Volume178
Nummer van het tijdschrift3
DOI's
StatusPublished - mrt-2018

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