HOMOZYGOUS DELETION IN A SMALL-CELL LUNG-CANCER CELL-LINE INVOLVING A 3P21 REGION WITH A MARKED INSTABILITY IN YEAST ARTIFICIAL CHROMOSOMES

K KOK; Anke van den Berg; PMJF VELDHUIS; AY VANDERVEEN; M FRANKE; EFPM SCHOENMAKERS; MMF HULSBEEK; AH VANDERHOUT; L DELEIJ; W VANDEVEN; CHCM BUYS

HOMOZYGOUS DELETION IN A SMALL-CELL LUNG-CANCER CELL-LINE INVOLVING A 3P21 REGION WITH A MARKED INSTABILITY IN YEAST ARTIFICIAL CHROMOSOMES

K KOK, Anke van den Berg, PMJF VELDHUIS, AY VANDERVEEN, M FRANKE, EFPM SCHOENMAKERS, MMF HULSBEEK, AH VANDERHOUT, L DELEIJ, W VANDEVEN, CHCM BUYS

Translational Immunology Groningen (TRIGR)

Onderzoeksoutput › Academic › peer review

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All types of lung carcinoma are characterized by a high frequency of loss of sequences from the short arm of chromosome 3, the smallest region of overlap containing D3F15S2 in band p21. Here we characterize a 440-kilobase segment from this region, which we found homozygously deleted in one of our small cell lung cancer-derived cell lines. The homozygous deletion maps between UBE1L and ZnF16, just centromeric to D3F15S2. Yeast artificial chromosomes with inserts originating from the deleted region are very unstable and readily lose parts of their insert.

Originele taal-2	English
Pagina's (van-tot)	4183-4187
Aantal pagina's	5
Tijdschrift	Cancer Research
Volume	54
Nummer van het tijdschrift	15
Status	Published - 1-aug.-1994

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@article{ebf5ec4281ee4c6b937a50f079742ec9,

title = "HOMOZYGOUS DELETION IN A SMALL-CELL LUNG-CANCER CELL-LINE INVOLVING A 3P21 REGION WITH A MARKED INSTABILITY IN YEAST ARTIFICIAL CHROMOSOMES",

abstract = "All types of lung carcinoma are characterized by a high frequency of loss of sequences from the short arm of chromosome 3, the smallest region of overlap containing D3F15S2 in band p21. Here we characterize a 440-kilobase segment from this region, which we found homozygously deleted in one of our small cell lung cancer-derived cell lines. The homozygous deletion maps between UBE1L and ZnF16, just centromeric to D3F15S2. Yeast artificial chromosomes with inserts originating from the deleted region are very unstable and readily lose parts of their insert.",

keywords = "INSITU HYBRIDIZATION, REDUCED EXPRESSION, DNA-SEQUENCE, SHORT ARM, CARCINOMA, GENES, HETEROZYGOSITY, TUMORIGENICITY, LOCALIZATION, DEFINES",

author = "K KOK and {van den Berg}, Anke and PMJF VELDHUIS and AY VANDERVEEN and M FRANKE and EFPM SCHOENMAKERS and MMF HULSBEEK and AH VANDERHOUT and L DELEIJ and W VANDEVEN and CHCM BUYS",

year = "1994",

month = aug,

day = "1",

language = "English",

volume = "54",

pages = "4183--4187",

journal = "Cancer Research",

issn = "0008-5472",

publisher = "AMER ASSOC CANCER RESEARCH",

number = "15",

}

TY - JOUR

T1 - HOMOZYGOUS DELETION IN A SMALL-CELL LUNG-CANCER CELL-LINE INVOLVING A 3P21 REGION WITH A MARKED INSTABILITY IN YEAST ARTIFICIAL CHROMOSOMES

AU - KOK, K

AU - van den Berg, Anke

AU - VELDHUIS, PMJF

AU - VANDERVEEN, AY

AU - FRANKE, M

AU - SCHOENMAKERS, EFPM

AU - HULSBEEK, MMF

AU - VANDERHOUT, AH

AU - DELEIJ, L

AU - VANDEVEN, W

AU - BUYS, CHCM

PY - 1994/8/1

Y1 - 1994/8/1

N2 - All types of lung carcinoma are characterized by a high frequency of loss of sequences from the short arm of chromosome 3, the smallest region of overlap containing D3F15S2 in band p21. Here we characterize a 440-kilobase segment from this region, which we found homozygously deleted in one of our small cell lung cancer-derived cell lines. The homozygous deletion maps between UBE1L and ZnF16, just centromeric to D3F15S2. Yeast artificial chromosomes with inserts originating from the deleted region are very unstable and readily lose parts of their insert.

AB - All types of lung carcinoma are characterized by a high frequency of loss of sequences from the short arm of chromosome 3, the smallest region of overlap containing D3F15S2 in band p21. Here we characterize a 440-kilobase segment from this region, which we found homozygously deleted in one of our small cell lung cancer-derived cell lines. The homozygous deletion maps between UBE1L and ZnF16, just centromeric to D3F15S2. Yeast artificial chromosomes with inserts originating from the deleted region are very unstable and readily lose parts of their insert.

KW - INSITU HYBRIDIZATION

KW - REDUCED EXPRESSION

KW - DNA-SEQUENCE

KW - SHORT ARM

KW - CARCINOMA

KW - GENES

KW - HETEROZYGOSITY

KW - TUMORIGENICITY

KW - LOCALIZATION

KW - DEFINES

M3 - Article

SN - 0008-5472

VL - 54

SP - 4183

EP - 4187

JO - Cancer Research

JF - Cancer Research

IS - 15

ER -

HOMOZYGOUS DELETION IN A SMALL-CELL LUNG-CANCER CELL-LINE INVOLVING A 3P21 REGION WITH A MARKED INSTABILITY IN YEAST ARTIFICIAL CHROMOSOMES

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