Hydrogen sulfide: Protective properties in models of disease

Pauline Snijder

Hydrogen sulfide: Protective properties in models of disease

Vertaalde titel van de bijdrage: Waterstofsulfide: Beschermende eigenschappen in ziektemodellen

Pauline Snijder

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Waterstofsulfide (H2S), een gas bekend van de geur van rotte eieren, is in staat om de zuurstofvraag in het lichaam te verlagen. Het kan namelijk een winterslaap-achtige staat induceren, waarbij het metabolisme met meer dan 90% wordt verminderd. Dit proefschrift laat zien dat deze eigenschap gebruikt kan worden om het hart te beschermen tijdens perioden van zuurstofgebrek. De afgelopen jaren zijn nieuwe functies van H2S in het lichaam gevonden. Zo blijkt het in veel celtypen te worden gemaakt en speelt het een rol bij een aantal (patho)-fysiologische processen zoals regulatie van de bloeddruk, ontstekingsprocessen en de activiteit van verschillende eiwitten. Dit proefschrift richt zich op de beschermende effecten van H2S in verschillende ziektemodellen waarin vergelijkbare schadeprocessen centraal staan. Zo laten we zien dat H2S kan hart en nieren kan beschermen tegen schade door hoge bloeddruk, maar ook dat H2S beschermend werkt in een model voor neurodegeneratie in fruitvliegen. Tevens hebben we verschillende doseringen en toedieningswegen onderzocht om zo een brug naar klinische toepassing van H2S te slaan.

Vertaalde titel van de bijdrage	Waterstofsulfide: Beschermende eigenschappen in ziektemodellen
Originele taal-2	English
Kwalificatie	Doctor of Philosophy
Toekennende instantie	Rijksuniversiteit Groningen
Begeleider(s)/adviseur	van Goor, Harry, Supervisor Leuvenink, Henri, Supervisor
Datum van toekenning	1-dec.-2014
Plaats van publicatie	[S.l.]
Uitgever	[S.n.]
Gedrukte ISBN's	978-90-367-7343-0
Elektronische ISBN's	978-90-367-7342-3
Status	Published - 2014

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Title and contents Final publisher's version, 50,5 KB
Chapter 1 Final publisher's version, 130 KB
Chapter 2 Final publisher's version, 244 KB
Chapter 3 Final publisher's version, 348 KB
Chapter 4 Final publisher's version, 1,68 MB
Chapter 5 Final publisher's version, 514 KB
Chapter 6 Final publisher's version, 307 KB
Chapter 7 Final publisher's version, 461 KB
Chapter 8 Final publisher's version, 70,1 KB
Chapter 9 Final publisher's version, 77,4 KB
Chapter 10 Final publisher's version, 109 KB
Complete dissertationFinal publisher's version, 3,26 MB
PropositionsFinal publisher's version, 36 KB

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title = "Hydrogen sulfide: Protective properties in models of disease",

abstract = "Hydrogen Sulfide (H2S) is a gas with the characteristic smell of rotten eggs. H2S can induce a hypometabolic, hibernation-like state that is characterized by reduced oxygen consumption and carbon dioxide production. In this thesis we used this feature to protect the heart during episodes of oxygen depletion. Recently, this pungent gas was discovered to be synthesized enzymatically in mammalian and human tissues in low concentrations, which positively transformed the apparent image of H2S into a promising therapeutic compound. H2S is important in the regulation of blood pressure, inflammatory processes and the activity of several proteins. This thesis addresses the protective effects of H2S in several models of disease where similar damaging processes are important. We show that H2S protects heart and kidneys from high blood pressure related damage. Also, we found that H2S decreases neurodegeneration in a fruit fly model. Furthermore, we investigated different dosages and modes of administration to pave the way for clinical use of H2S-based therapy.",

author = "Pauline Snijder",

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T2 - Protective properties in models of disease

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N2 - Hydrogen Sulfide (H2S) is a gas with the characteristic smell of rotten eggs. H2S can induce a hypometabolic, hibernation-like state that is characterized by reduced oxygen consumption and carbon dioxide production. In this thesis we used this feature to protect the heart during episodes of oxygen depletion. Recently, this pungent gas was discovered to be synthesized enzymatically in mammalian and human tissues in low concentrations, which positively transformed the apparent image of H2S into a promising therapeutic compound. H2S is important in the regulation of blood pressure, inflammatory processes and the activity of several proteins. This thesis addresses the protective effects of H2S in several models of disease where similar damaging processes are important. We show that H2S protects heart and kidneys from high blood pressure related damage. Also, we found that H2S decreases neurodegeneration in a fruit fly model. Furthermore, we investigated different dosages and modes of administration to pave the way for clinical use of H2S-based therapy.

AB - Hydrogen Sulfide (H2S) is a gas with the characteristic smell of rotten eggs. H2S can induce a hypometabolic, hibernation-like state that is characterized by reduced oxygen consumption and carbon dioxide production. In this thesis we used this feature to protect the heart during episodes of oxygen depletion. Recently, this pungent gas was discovered to be synthesized enzymatically in mammalian and human tissues in low concentrations, which positively transformed the apparent image of H2S into a promising therapeutic compound. H2S is important in the regulation of blood pressure, inflammatory processes and the activity of several proteins. This thesis addresses the protective effects of H2S in several models of disease where similar damaging processes are important. We show that H2S protects heart and kidneys from high blood pressure related damage. Also, we found that H2S decreases neurodegeneration in a fruit fly model. Furthermore, we investigated different dosages and modes of administration to pave the way for clinical use of H2S-based therapy.

M3 - Thesis fully internal (DIV)

SN - 978-90-367-7343-0

PB - [S.n.]

CY - [S.l.]

ER -

Hydrogen sulfide: Protective properties in models of disease

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