TY - JOUR
T1 - Hypercalcemia in a patient with disseminated paracoccidioidomycosis
T2 - A case report
AU - Almeida, Rafael Moura
AU - Cezana, Loureno
AU - Tsukumo, Daniela Miti Lemos
AU - de Carvalho-Filho, Marco Antônio
AU - Saad, Mário José Abdalla
PY - 2008/8/8
Y1 - 2008/8/8
N2 - Introduction: Hypercalcemia is well described in various granulomatous disorders, such as sarcoidosis, tuberculosis, berylliosis, leprosy and fungal infections. However, the association of Paracoccidioides brasiliensis and hypercalcemia is rare: to the best of our knowledge, only two cases have previously been reported, and neither had a clear documentation of the etiology of the hypercalcemia. Case presentation: We report the case of a 22-year-old man in whom disseminated infection with paracoccidioidomycosis was associated with hypercalcemia. The patient had a high normal serum level of 1,25-dihydroxyvitamin D and a suppressed parathyroid hormone value, an indication that the hypercalcemia was not mediated by parathyroid hormone and might be associated with 1,25-dihydroxyvitamin D. Conclusion: The episode resolved readily with administration of corticosteroids, an outcome suggesting that this is an effective treatment of hypercalcemia of this origin. On follow-up, while receiving antifungal therapy for P. brasiliensis the patient's calcium values remained normal.
AB - Introduction: Hypercalcemia is well described in various granulomatous disorders, such as sarcoidosis, tuberculosis, berylliosis, leprosy and fungal infections. However, the association of Paracoccidioides brasiliensis and hypercalcemia is rare: to the best of our knowledge, only two cases have previously been reported, and neither had a clear documentation of the etiology of the hypercalcemia. Case presentation: We report the case of a 22-year-old man in whom disseminated infection with paracoccidioidomycosis was associated with hypercalcemia. The patient had a high normal serum level of 1,25-dihydroxyvitamin D and a suppressed parathyroid hormone value, an indication that the hypercalcemia was not mediated by parathyroid hormone and might be associated with 1,25-dihydroxyvitamin D. Conclusion: The episode resolved readily with administration of corticosteroids, an outcome suggesting that this is an effective treatment of hypercalcemia of this origin. On follow-up, while receiving antifungal therapy for P. brasiliensis the patient's calcium values remained normal.
U2 - 10.1186/1752-1947-2-262
DO - 10.1186/1752-1947-2-262
M3 - Article
AN - SCOPUS:51049085818
SN - 1752-1947
VL - 2
JO - Journal of Medical Case Reports
JF - Journal of Medical Case Reports
M1 - 262
ER -