TY - JOUR
T1 - Hyperglycaemia in critically ill patients: marker or mediator of mortality?
AU - Corstjens, Anouk M.
AU - van der Horst, Iwan C. C.
AU - Groeneveld, A. B. Johan
AU - Zijlstra, Felix
AU - Tulleken, Jaap E.
AU - Ligtenberg, Jack J. M.
AU - Zijlstra, Jan
PY - 2006
Y1 - 2006
N2 - Acute hyperglycaemia has been associated with complications, prolonged intensive care unit and hospital stay, and increased mortality. We made an inventory of the prevalence and prognostic value of hyperglycaemia, and of the effects of glucose control in different groups of critically ill patients. The prevalence of hyperglycaemia in critically ill patients, using stringent criteria, approaches 100%. An unambiguous negative correlation between hyperglycaemia and mortality has been described in various groups of critically ill patients. Although the available evidence remains inconsistent, there appears to be a favourable effect of glucose regulation. This effect on morbidity and mortality depends on patient characteristics. To be able to compare results of future studies involving glucose regulation, better definitions of hyperglycaemia ( and consequently of normoglycaemia) and patient populations are needed.
AB - Acute hyperglycaemia has been associated with complications, prolonged intensive care unit and hospital stay, and increased mortality. We made an inventory of the prevalence and prognostic value of hyperglycaemia, and of the effects of glucose control in different groups of critically ill patients. The prevalence of hyperglycaemia in critically ill patients, using stringent criteria, approaches 100%. An unambiguous negative correlation between hyperglycaemia and mortality has been described in various groups of critically ill patients. Although the available evidence remains inconsistent, there appears to be a favourable effect of glucose regulation. This effect on morbidity and mortality depends on patient characteristics. To be able to compare results of future studies involving glucose regulation, better definitions of hyperglycaemia ( and consequently of normoglycaemia) and patient populations are needed.
KW - ACUTE MYOCARDIAL-INFARCTION
KW - GLUCOSE-INSULIN-POTASSIUM
KW - TIGHT GLYCEMIC CONTROL
KW - ADMISSION HYPERGLYCEMIA
KW - HOSPITAL MORTALITY
KW - DIABETES-MELLITUS
KW - STRESS HYPERGLYCEMIA
KW - TRAUMA PATIENTS
KW - BLOOD-GLUCOSE
KW - MEDICAL ICU
U2 - 10.1186/cc4957
DO - 10.1186/cc4957
M3 - Review article
SN - 1466-609X
VL - 10
JO - Critical Care
JF - Critical Care
IS - 3
M1 - 216
ER -