ICU acquired hypernatremia treated by enteral free water - A retrospective cohort study

Elisabeth A. J. de Vos*, Peter H. J. van der Voort

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

2 Citaten (Scopus)
18 Downloads (Pure)


Purpose: ICU acquired hypernatremia (IAH) is associated with increased morbidity and mortality, however treat-ment remains controversial. This study aims to determine the effect of enteral free water suppletion in patients with IAH.

Materials and methods: Retrospective single center study in a tertiary ICU. Inclusion criteria: patients with IAH and treatment with enteral free water. Exclusion criteria: patients with renal replacement therapy, diabetic ketoacidosis or hyperosmolar hyperglycaemic state. Primary outcome: change in plasma sodium (in mmol/l) after 5 days treatment. Responders were defined as patients with a decrease in sodium level of 5 mmol/l or more.

Results: In total 382 consecutive patients were included. The median sodium level at the start of water therapy was 149 mmol/l (IQR 147-150). The median volume of enteral water was 4423 ml (IQR 3349-5379 ml) after 5 days and mean sodium decrease was 1.87 mmol/l (SD 4.84). There was no significant correlation between the volume of enteral water and sodium decrease (r(2) = 0.01).

Conclusions: Treatment with enteral free water did not result in a clinically relevant decrease in serum sodium level in patients with IAH. In addition, the volume of enteral free water and the use of diuretics was unrelated with sodium change over 5 days. (C) 2020 Elsevier Inc. All rights reserved.

Originele taal-2English
Pagina's (van-tot)72-75
Aantal pagina's4
TijdschriftJournal of Critical Care
StatusPublished - apr-2021

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