Identification of a novel genomic island associated with vanD-type vancomycin-resistance in six Dutch vancomycin-resistant Enterococcus faecium

Janetta Top; Jan C Sinnige; Ellen C Brouwer; Guido Werner; Jukka Corander; Juliëtte A Severin; Rogier Jansen; E Bathoorn; Marc J M Bonten; John W A Rossen; Rob J L Willems

doi:10.1128/AAC.01793-17

Identification of a novel genomic island associated with vanD-type vancomycin-resistance in six Dutch vancomycin-resistant Enterococcus faecium

Janetta Top, Jan C Sinnige, Ellen C Brouwer, Guido Werner, Jukka Corander, Juliëtte A Severin, Rogier Jansen, E Bathoorn, Marc J M Bonten, John W A Rossen, Rob J L Willems

Microbes in Health and Disease (MHD)

Onderzoeksoutput › Academic › peer review

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Genomic comparison of the first six Dutch vanD-type vancomycin-resistant Enterococcus faecium (VRE) with four vanD-gene clusters from other enterococcal species and anaerobic gut commensals revealed that the vanD-gene cluster was located on a genomic island of variable size. Phylogenetic inferences revealed that the Dutch-VRE were genetically not closely related and genetic variation of the vanD-genomic island was not species specific, which suggest that this island is transferred horizontally between enterococci and anaerobic gut commensals.

Originele taal-2	English
Artikelnummer	e01793-17
Tijdschrift	Antimicrobial Agents and Chemotherapy
Volume	62
Nummer van het tijdschrift	3
Vroegere onlinedatum	8-jan.-2018
DOI's	https://doi.org/10.1128/AAC.01793-17
Status	Published - mrt.-2018

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Top, J., Sinnige, J. C., Brouwer, E. C., Werner, G., Corander, J., Severin, J. A., Jansen, R., Bathoorn, E., Bonten, M. J. M., Rossen, J. W. A., & Willems, R. J. L. (2018). Identification of a novel genomic island associated with vanD-type vancomycin-resistance in six Dutch vancomycin-resistant Enterococcus faecium. Antimicrobial Agents and Chemotherapy, 62(3), Artikel e01793-17. https://doi.org/10.1128/AAC.01793-17

@article{a851294300324098b3e65063ac575c1a,

title = "Identification of a novel genomic island associated with vanD-type vancomycin-resistance in six Dutch vancomycin-resistant Enterococcus faecium",

abstract = "Genomic comparison of the first six Dutch vanD-type vancomycin-resistant Enterococcus faecium (VRE) with four vanD-gene clusters from other enterococcal species and anaerobic gut commensals revealed that the vanD-gene cluster was located on a genomic island of variable size. Phylogenetic inferences revealed that the Dutch-VRE were genetically not closely related and genetic variation of the vanD-genomic island was not species specific, which suggest that this island is transferred horizontally between enterococci and anaerobic gut commensals.",

keywords = "Journal Article, CANADA, FLORA, MOLECULAR CHARACTERIZATION, CONJUGATIVE ELEMENTS, GENE-CLUSTER, FAECALIS",

author = "Janetta Top and Sinnige, {Jan C} and Brouwer, {Ellen C} and Guido Werner and Jukka Corander and Severin, {Juli{\"e}tte A} and Rogier Jansen and E Bathoorn and Bonten, {Marc J M} and Rossen, {John W A} and Willems, {Rob J L}",

note = "Copyright {\textcopyright} 2018 American Society for Microbiology.",

year = "2018",

month = mar,

doi = "10.1128/AAC.01793-17",

language = "English",

volume = "62",

journal = "Antimicrobial Agents and Chemotherapy",

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number = "3",

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Top, J, Sinnige, JC, Brouwer, EC, Werner, G, Corander, J, Severin, JA, Jansen, R, Bathoorn, E, Bonten, MJM, Rossen, JWA & Willems, RJL 2018, 'Identification of a novel genomic island associated with vanD-type vancomycin-resistance in six Dutch vancomycin-resistant Enterococcus faecium', Antimicrobial Agents and Chemotherapy, vol. 62, nr. 3, e01793-17. https://doi.org/10.1128/AAC.01793-17

TY - JOUR

T1 - Identification of a novel genomic island associated with vanD-type vancomycin-resistance in six Dutch vancomycin-resistant Enterococcus faecium

AU - Top, Janetta

AU - Sinnige, Jan C

AU - Brouwer, Ellen C

AU - Werner, Guido

AU - Corander, Jukka

AU - Severin, Juliëtte A

AU - Jansen, Rogier

AU - Bathoorn, E

AU - Bonten, Marc J M

AU - Rossen, John W A

AU - Willems, Rob J L

PY - 2018/3

Y1 - 2018/3

N2 - Genomic comparison of the first six Dutch vanD-type vancomycin-resistant Enterococcus faecium (VRE) with four vanD-gene clusters from other enterococcal species and anaerobic gut commensals revealed that the vanD-gene cluster was located on a genomic island of variable size. Phylogenetic inferences revealed that the Dutch-VRE were genetically not closely related and genetic variation of the vanD-genomic island was not species specific, which suggest that this island is transferred horizontally between enterococci and anaerobic gut commensals.

AB - Genomic comparison of the first six Dutch vanD-type vancomycin-resistant Enterococcus faecium (VRE) with four vanD-gene clusters from other enterococcal species and anaerobic gut commensals revealed that the vanD-gene cluster was located on a genomic island of variable size. Phylogenetic inferences revealed that the Dutch-VRE were genetically not closely related and genetic variation of the vanD-genomic island was not species specific, which suggest that this island is transferred horizontally between enterococci and anaerobic gut commensals.

KW - Journal Article

KW - CANADA

KW - FLORA

KW - MOLECULAR CHARACTERIZATION

KW - CONJUGATIVE ELEMENTS

KW - GENE-CLUSTER

KW - FAECALIS

U2 - 10.1128/AAC.01793-17

DO - 10.1128/AAC.01793-17

M3 - Article

C2 - 29311068

SN - 1098-6596

VL - 62

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 3

M1 - e01793-17

ER -

Identification of a novel genomic island associated with vanD-type vancomycin-resistance in six Dutch vancomycin-resistant Enterococcus faecium

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