Identification of Risk Factors for Dupilumab-associated OculaSurface Disease in Patients with Atopic Dermatitis

Roselie E. Achten*, Chantal M. van Luijk, Lisa P. van der Rijst, Daphne S. Bakker, Lotte S. Spekhorst, Nicolaas P.A. Zuithoff, Marie L.A. Schuttelaar, Geertruida L.E. Romeijn, Angelique N. Voorberg, Marijke Kamsteeg, Inge M. Haeck, Marlies de Graaf, Judith L. Thijs, Joke H. de Boer, Marjolein S. de Bruin-Weller

*Corresponding author voor dit werk

OnderzoeksoutputAcademicpeer review

6 Citaten (Scopus)
63 Downloads (Pure)

Samenvatting

This study identified risk factors for the development of dupilumab-associated ocular surface disease in patients with moderate-to-severe atopic dermatitis in a large prospective daily practice cohort. Data from the Dutch BioDay Registry were used to assess the risk of developing dupilumab-associated ocular surface di-sease, by performing univariate and multivariate logistic regression analyses. A total of 469 patients were included, of which 152/469 (32.4%) developed dupi-lumab-associated ocular surface disease. Multivariate analysis showed a statistically significant association of the development of dupilumab-associated ocular surface disease with a history of any eye disease (his-tory of self-reported episodic acute allergic conjunctivitis excluded) combined with the use of ophthalmic medication at the start of dupilumab (odds ratio 5.16, 95% confidence interval 2.30–11.56, p < 0.001). In conclusion, a history of any eye disease (history of self-reported episodic acute allergic conjunctivitis ex-cluded) combined with the use of ophthalmic medication at baseline was associated with the development of dupilumab-associated ocular surface disease in patients with atopic dermatitis.

Originele taal-2English
Artikelnummeradv00666
Aantal pagina's7
TijdschriftActa dermato-venereologica
Volume102
DOI's
StatusPublished - 2022

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