Immunophenotypes of malignant lymphoma centroblastic-centrocytic and malignant lymphoma centrocytic: An immunohistologic study indicating a derivation from different stages of B cell differentiation

Harry Hollema*, Sibrand Poppema

*Bijbehorende auteur voor dit werk

    OnderzoeksoutputAcademicpeer review

    26 Citaten (Scopus)


    Five cases of intermediate lymphocytic lymphoma (ILL), 13 cases of malignant lymphoma centrocytic (MLCC), and 27 cases of malignant lymphoma centroblastic centrocytic (MLCBCC) were studied morphologically and with the aid of a panel of monoclonal antibodies. The immunophenotypes of ILL and MLCC (IgM+/IgD+, MT1+, CALLA−) indicate a mantle zone or very early follicle center derivation. The immunophenotypes of MLCBCC (IgM+ or IgG/IgA+, MT1−, CALLA+) indicate a “true” follicle center derivation. The morphologic diversity of MLCBCC could not be related to specific immunophenotypes.
    Originele taal-2English
    Pagina's (van-tot)1053-1059
    Aantal pagina's7
    TijdschriftHuman Pathology
    Nummer van het tijdschrift9
    StatusPublished - sep-1988

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