Impaired hypoxic tolerance in APP23 mice: A dysregulation of neuroprotective globin levels

Zoe P. Van Acker, Evi Luyckx, Wendy Van Leuven, Eva Geuens, Peter P. De Deyn, Debby Van Dam, Sylvia Dewilde*

*Bijbehorende auteur voor dit werk

Onderzoeksoutput: LetterAcademicpeer review

5 Citaten (Scopus)
278 Downloads (Pure)


Although neuroglobin confers neuroprotection against Alzheimer's disease (AD) pathology, its expression becomes downregulated in late-stage AD. Here, we provide evidence that indicates that this decrease is associated with the AD-linked angiopathy. While wild-type mice of different ages show upregulated cerebral neuroglobin expression upon whole-body hypoxia, APP23 mice exhibit decreased cerebral transcription of neuroglobin. Interestingly, transcription of cytoglobin, whose involvement in amyloid pathology still needs to be elucidated, follows a similar pattern. To further unravel the underlying mechanism, we examined the expression levels of the RE-1-silencing transcription factor (REST/NRSF) after identifying a recognition site for it in the regulatory region of both globins. Neuroglobin-cytoglobin-REST/NRSF expression correlations are detected mainly in the cortex. This raises the possibility of REST/NRSF being an upstream regulator of these globins.

Originele taal-2English
Pagina's (van-tot)1321-1332
Aantal pagina's12
TijdschriftFEBS Letters
Nummer van het tijdschrift10
StatusPublished - mei-2017

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