Implications of antiretroviral resistance on viral fitness

M Nijhuis; S Deeks; C Boucher

Implications of antiretroviral resistance on viral fitness

M Nijhuis^*
, S Deeks
, C Boucher

^*Corresponding author voor dit werk

Rijksuniversiteit Groningen

Onderzoeksoutput › peer review

171 Citaten (Scopus)

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Treatment of HIV infected patients with antiretroviral drugs often results in the emergence of virus variants with reduced sensitivity to these drugs. However, the viral load often remains partially suppressed below pretherapy levels, which might be explained by a reduced fitness of the drug resistant viral population. This review describes the effects of antiretroviral resistance development on the fitness of the viral population and its clinical implications. Curr Opin Infect Dis 14:23-28. (C) 2001 Lippincott Williams & Wilkins.

Originele taal-2	English
Pagina's (van-tot)	23-28
Aantal pagina's	6
Tijdschrift	Current opinion in infectious diseases
Volume	14
Nummer van het tijdschrift	1
Status	Published - feb-2001

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@article{0f4c3952c65b499c9c1918fbbf779478,

title = "Implications of antiretroviral resistance on viral fitness",

abstract = "Treatment of HIV infected patients with antiretroviral drugs often results in the emergence of virus variants with reduced sensitivity to these drugs. However, the viral load often remains partially suppressed below pretherapy levels, which might be explained by a reduced fitness of the drug resistant viral population. This review describes the effects of antiretroviral resistance development on the fitness of the viral population and its clinical implications. Curr Opin Infect Dis 14:23-28. (C) 2001 Lippincott Williams \& Wilkins.",

keywords = "IMMUNODEFICIENCY-VIRUS TYPE-1, HIGH-LEVEL RESISTANCE, REVERSE-TRANSCRIPTASE, PROTEASE INHIBITORS, IN-VIVO, REPLICATIVE FITNESS, COMBINATION THERAPY, DRUG-RESISTANCE, POL GENE, ZIDOVUDINE",

author = "M Nijhuis and S Deeks and C Boucher",

year = "2001",

month = feb,

language = "English",

volume = "14",

pages = "23--28",

journal = "Current opinion in infectious diseases",

issn = "0951-7375",

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TY - JOUR

T1 - Implications of antiretroviral resistance on viral fitness

AU - Nijhuis, M

AU - Deeks, S

AU - Boucher, C

PY - 2001/2

Y1 - 2001/2

N2 - Treatment of HIV infected patients with antiretroviral drugs often results in the emergence of virus variants with reduced sensitivity to these drugs. However, the viral load often remains partially suppressed below pretherapy levels, which might be explained by a reduced fitness of the drug resistant viral population. This review describes the effects of antiretroviral resistance development on the fitness of the viral population and its clinical implications. Curr Opin Infect Dis 14:23-28. (C) 2001 Lippincott Williams & Wilkins.

AB - Treatment of HIV infected patients with antiretroviral drugs often results in the emergence of virus variants with reduced sensitivity to these drugs. However, the viral load often remains partially suppressed below pretherapy levels, which might be explained by a reduced fitness of the drug resistant viral population. This review describes the effects of antiretroviral resistance development on the fitness of the viral population and its clinical implications. Curr Opin Infect Dis 14:23-28. (C) 2001 Lippincott Williams & Wilkins.

KW - IMMUNODEFICIENCY-VIRUS TYPE-1

KW - HIGH-LEVEL RESISTANCE

KW - REVERSE-TRANSCRIPTASE

KW - PROTEASE INHIBITORS

KW - IN-VIVO

KW - REPLICATIVE FITNESS

KW - COMBINATION THERAPY

KW - DRUG-RESISTANCE

KW - POL GENE

KW - ZIDOVUDINE

M3 - Review article

SN - 0951-7375

VL - 14

SP - 23

EP - 28

JO - Current opinion in infectious diseases

JF - Current opinion in infectious diseases

IS - 1

ER -

Implications of antiretroviral resistance on viral fitness

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