Importance of fluorodeoxyglucose-positron emission tomography (FDG-PET) and endoscopic ultrasonography parameters in predicting survival following surgery for esophageal cancer

J. M. T. Omloo*, G. W. Sloof, R. Boellaard, O. S. Hoekstra, P. L. Jager, H. M. van Dullemen, P. Fockens, J. T. M. Plukker, J. J. B. van Lanschot

*Bijbehorende auteur voor dit werk

Onderzoeksoutput: ArticleAcademicpeer review

40 Citaten (Scopus)


Background and study aims: To assess the prognostic importance of standardized uptake value (SUV) for 18F-fluorodeoxyglucose (FDG) at positron emission tomography (PET) and of EUS parameters, in esophageal cancer patients primarily treated by surgery.

Patients and methods: Between October 2002 and August 2004 a prospective cohort study involved 125 patients, with histologically proven cancer of the esophagus, without evidence of distant metastases or locally irresectable disease based on extensive preoperative work-up, and fit to undergo major surgery. Follow-up was complete until October 2006, ensuring a minimal potential follow-up of 25 months.

Results: The median SUV was 0.27 (interquartile range 0.13-0.45), and was used as cutoff valuebetween high (n=62) and low (n=63) SUV. Patients with a high SUV had a significantly worse disease-specific survival compared with patients with a low SUV (P = 0.04). Tumor location (P =0.005), EUS T stage (P <0.001), EUS N stage (P= 0.006) and clinical stage (P <0.006) were also associated with disease-specific survival. However, in multivariate analysis only EUS T stage appeared to be of independent prognostic significance (P =0.007).

Conclusion: In esophageal cancer patients, EUS T stage, EUS N stage, location and SUV of the primary tumor are pretreatment factors that are associated with disease-specific survival. However, only EUS T stage is an independent prognostic factor.

Originele taal-2English
Pagina's (van-tot)464-471
Aantal pagina's8
Nummer van het tijdschrift6
StatusPublished - jun.-2008

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