TY - JOUR
T1 - Improved detection of localized prostate cancer using co-registered MRI and C-11-acetate PET/CT
AU - Jambor, Ivan
AU - Borra, Ronald
AU - Kemppainen, Jukka
AU - Lepomaki, Virva
AU - Parkkola, Riitta
AU - Dean, Kirsti
AU - Alanen, Kalle
AU - Arponen, Eveliina
AU - Nurmi, Martti
AU - Aronen, Hannu J.
AU - Minn, Heikki
PY - 2012/11
Y1 - 2012/11
N2 - Objectives: We aimed to study the ability of contrast enhanced MRI at 1.5 T and C-11-acetate PET/CT, both individually and using fused data, to detect localized prostate cancer.Methods: Thirty-six men with untreated prostate cancer and negative for metastatic disease on pelvic CT and bone scan were prospectively enrolled. A pelvic C-11-acetate PET/CT scan was performed in all patients, and a contrast enhanced MRI scan in 33 patients (6 examinations using both endorectal coil and surface coils, and 27 examinations using surface coils only). After the imaging studies 10 patients underwent prostatectomy and 26 were treated by image guided external beam radiation treatment. Image fusion of co-registered PET and MRI data was performed based on anatomical landmarks visible on CT and MRI using an advanced in-house developed software package. PET/CT, MRI and fused PET/MRI data were evaluated visually and compared with biopsy findings on a lobar level, while a sextant approach was used for patients undergoing prostatectomy.Results: When using biopsy samples as method of reference, the sensitivity, specificity and accuracy for visual detection of prostate cancer on a lobar level by contrast enhanced MRI was 85%, 37%, 73% and that of C-11-acetate PET/CT 88%, 41%, 74%, respectively. Fusion of PET with MRI data increased sensitivity, specificity and accuracy to 90%, 72% and 85%, respectively.Conclusions: Fusion of sequentially obtained PET/CT and MRI data for the localization of prostate cancer is feasible and superior to the performance of each individual modality alone. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
AB - Objectives: We aimed to study the ability of contrast enhanced MRI at 1.5 T and C-11-acetate PET/CT, both individually and using fused data, to detect localized prostate cancer.Methods: Thirty-six men with untreated prostate cancer and negative for metastatic disease on pelvic CT and bone scan were prospectively enrolled. A pelvic C-11-acetate PET/CT scan was performed in all patients, and a contrast enhanced MRI scan in 33 patients (6 examinations using both endorectal coil and surface coils, and 27 examinations using surface coils only). After the imaging studies 10 patients underwent prostatectomy and 26 were treated by image guided external beam radiation treatment. Image fusion of co-registered PET and MRI data was performed based on anatomical landmarks visible on CT and MRI using an advanced in-house developed software package. PET/CT, MRI and fused PET/MRI data were evaluated visually and compared with biopsy findings on a lobar level, while a sextant approach was used for patients undergoing prostatectomy.Results: When using biopsy samples as method of reference, the sensitivity, specificity and accuracy for visual detection of prostate cancer on a lobar level by contrast enhanced MRI was 85%, 37%, 73% and that of C-11-acetate PET/CT 88%, 41%, 74%, respectively. Fusion of PET with MRI data increased sensitivity, specificity and accuracy to 90%, 72% and 85%, respectively.Conclusions: Fusion of sequentially obtained PET/CT and MRI data for the localization of prostate cancer is feasible and superior to the performance of each individual modality alone. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
KW - C-11-acetate PET/CT
KW - Multimodality imaging
KW - Image fusion
KW - Prostate cancer
KW - Dynamic contrast enhanced MRI
KW - POSITRON-EMISSION-TOMOGRAPHY
KW - CELL-PROLIFERATION
KW - REPRODUCIBILITY
KW - METABOLISM
KW - ACETATE
KW - BIOPSY
U2 - 10.1016/j.ejrad.2011.12.043
DO - 10.1016/j.ejrad.2011.12.043
M3 - Article
SN - 0720-048X
VL - 81
SP - 2966
EP - 2972
JO - European Journal of Radiology
JF - European Journal of Radiology
IS - 11
ER -