Improved healing of small-caliber polytetrafluoroethylene prostheses by induction of a clot layer: a review of experimental studies in rats

B. van der Lei*, J.W. Stronck, CRH WILDEVUUR

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

5 Citaten (Scopus)


This report reviews our experiments that have been undertaken to test the hypothesis whether the induction of a clot layer on the graft surface of small-caliber polytetrafluoroethylene ( PTFE) prostheses might improve their healing. 1 2 PTFE prostheses with a fibril length of 30-mu-m, PTFE prostheses with a fibril length of 30-mu-m and either impregnated with Chitosan, or pretreated with alcohol or mechanically roughened, and PTFE prostheses with a fibril length of 60-mu-m (all prostheses: length 1 cm, ID 1.5 mm) were implanted into the abdominal aorta of rats and were evaluated from 1 day up till 6 weeks after implantation with regard to the presence or absence of a clot layer and with regard to the amount of graft healing. All untreated PTFE prostheses were never found to be covered with a clot layer and showed poor neoendothelial healing: even at 6 weeks after implantation, there were only endothelial cells near the anastomotic sides, directly on the graft surface. In contrast, all other PTFE prostheses were completely covered with a clot layer upon implantation and demonstrated almost complete neoendothelial healing after 6 weeks. Moreover, in these prostheses, the endothelial cells were present on a matrix of smooth muscle cells. These results confirm our hypothesis that the induction of a clot layer on the graft surface of PTFE prostheses improves their healing: the clot probably functions as a provisional matrix for the regeneration of arterial wall tissue, just as occurs in normal arterial wall repair.

Originele taal-2English
Pagina's (van-tot)202-208
Aantal pagina's7
TijdschriftInternational angiology
Nummer van het tijdschrift4
StatusPublished - 1991

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