In preterm infants, ascending intrauterine infection is associated with lower cerebral tissue oxygen saturation and higher oxygen extraction

Annemiek M. Roescher; Albertus Timmer; Michelle E. van der Laan; Jan Jaap H. M. Erwich; Arend F. Bos; Elisabeth M. W. Kooi; Elise A. Verhagen

doi:10.1038/pr.2015.20

In preterm infants, ascending intrauterine infection is associated with lower cerebral tissue oxygen saturation and higher oxygen extraction

Annemiek M. Roescher^*, Albertus Timmer, Michelle E. van der Laan, Jan Jaap H. M. Erwich, Arend F. Bos, Elisabeth M. W. Kooi, Elise A. Verhagen

^*Corresponding author voor dit werk

Reproductive Origins of Adult Health and Disease (ROAHD)

Onderzoeksoutput › Academic › peer review

3 Citaten (Scopus)

Samenvatting

BACKGROUND: Placental lesions are associated with neurological morbidity but the mechanism leading to morbidity is unclear. To provide insight into such a possible mechanism, we determined whether placental lesions were associated with regional cerebral tissue oxygen saturation (r(c)SO(2)) and fractional tissue oxygen extraction (FTOE) in preterm infants during their first 5 d after birth. We hypothesized that as a result of cerebral hypoperfusion, rcSO2 would be lower and FTOE would be higher.

METHOD: In a prospective, observational study of 42 preterm infants (gestational age

RESULTS: Only three placentas showed no pathology. Ascending intrauterine infection (AlUI) (n = 16) was associated with lower r(c)SO(2) and higher FTOE values on days 2, 3, and 4 (P

CONCLUSION: AlUI is associated with lower r(c)SO(2), and higher FTOE shortly after birth. The effect it has on cerebral oxygenation might be the mechanism leading to neurodevelopmental problems.

Originele taal-2	English
Pagina's (van-tot)	688-695
Aantal pagina's	8
Tijdschrift	Pediatric Research
Volume	77
Nummer van het tijdschrift	5
DOI's	https://doi.org/10.1038/pr.2015.20
Status	Published - mei-2015

Toegang tot document

10.1038/pr.2015.20

Handle.net

Permanente koppeling

Document onder embargo

In preterm infants, ascending intrauterine infection is associated with lower
Final publisher's version, 219 KB
Kopie aanvragen

Citeer dit

@article{5f4642d16fce4d6fba81ff8ea03728cb,

title = "In preterm infants, ascending intrauterine infection is associated with lower cerebral tissue oxygen saturation and higher oxygen extraction",

abstract = "BACKGROUND: Placental lesions are associated with neurological morbidity but the mechanism leading to morbidity is unclear. To provide insight into such a possible mechanism, we determined whether placental lesions were associated with regional cerebral tissue oxygen saturation (r(c)SO(2)) and fractional tissue oxygen extraction (FTOE) in preterm infants during their first 5 d after birth. We hypothesized that as a result of cerebral hypoperfusion, rcSO2 would be lower and FTOE would be higher.METHOD: In a prospective, observational study of 42 preterm infants (gestational ageRESULTS: Only three placentas showed no pathology. Ascending intrauterine infection (AlUI) (n = 16) was associated with lower r(c)SO(2) and higher FTOE values on days 2, 3, and 4 (PCONCLUSION: AlUI is associated with lower r(c)SO(2), and higher FTOE shortly after birth. The effect it has on cerebral oxygenation might be the mechanism leading to neurodevelopmental problems.",

keywords = "PLACENTAL REACTION PATTERNS, INTRAVENTRICULAR HEMORRHAGE, HISTOLOGIC CHARACTERISTICS, NEUROLOGIC IMPAIRMENT, LESIONS, BIRTH, CHORIOAMNIONITIS, REPRODUCIBILITY, NOSOLOGY, PALSY",

author = "Roescher, {Annemiek M.} and Albertus Timmer and {van der Laan}, {Michelle E.} and Erwich, {Jan Jaap H. M.} and Bos, {Arend F.} and Kooi, {Elisabeth M. W.} and Verhagen, {Elise A.}",

year = "2015",

month = may,

doi = "10.1038/pr.2015.20",

language = "English",

volume = "77",

pages = "688--695",

journal = "Pediatric Research",

issn = "0031-3998",

publisher = "Nature Publishing Group",

number = "5",

}

TY - JOUR

T1 - In preterm infants, ascending intrauterine infection is associated with lower cerebral tissue oxygen saturation and higher oxygen extraction

AU - Roescher, Annemiek M.

AU - Timmer, Albertus

AU - van der Laan, Michelle E.

AU - Erwich, Jan Jaap H. M.

AU - Bos, Arend F.

AU - Kooi, Elisabeth M. W.

AU - Verhagen, Elise A.

PY - 2015/5

Y1 - 2015/5

N2 - BACKGROUND: Placental lesions are associated with neurological morbidity but the mechanism leading to morbidity is unclear. To provide insight into such a possible mechanism, we determined whether placental lesions were associated with regional cerebral tissue oxygen saturation (r(c)SO(2)) and fractional tissue oxygen extraction (FTOE) in preterm infants during their first 5 d after birth. We hypothesized that as a result of cerebral hypoperfusion, rcSO2 would be lower and FTOE would be higher.METHOD: In a prospective, observational study of 42 preterm infants (gestational ageRESULTS: Only three placentas showed no pathology. Ascending intrauterine infection (AlUI) (n = 16) was associated with lower r(c)SO(2) and higher FTOE values on days 2, 3, and 4 (PCONCLUSION: AlUI is associated with lower r(c)SO(2), and higher FTOE shortly after birth. The effect it has on cerebral oxygenation might be the mechanism leading to neurodevelopmental problems.

AB - BACKGROUND: Placental lesions are associated with neurological morbidity but the mechanism leading to morbidity is unclear. To provide insight into such a possible mechanism, we determined whether placental lesions were associated with regional cerebral tissue oxygen saturation (r(c)SO(2)) and fractional tissue oxygen extraction (FTOE) in preterm infants during their first 5 d after birth. We hypothesized that as a result of cerebral hypoperfusion, rcSO2 would be lower and FTOE would be higher.METHOD: In a prospective, observational study of 42 preterm infants (gestational ageRESULTS: Only three placentas showed no pathology. Ascending intrauterine infection (AlUI) (n = 16) was associated with lower r(c)SO(2) and higher FTOE values on days 2, 3, and 4 (PCONCLUSION: AlUI is associated with lower r(c)SO(2), and higher FTOE shortly after birth. The effect it has on cerebral oxygenation might be the mechanism leading to neurodevelopmental problems.

KW - PLACENTAL REACTION PATTERNS

KW - INTRAVENTRICULAR HEMORRHAGE

KW - HISTOLOGIC CHARACTERISTICS

KW - NEUROLOGIC IMPAIRMENT

KW - LESIONS

KW - BIRTH

KW - CHORIOAMNIONITIS

KW - REPRODUCIBILITY

KW - NOSOLOGY

KW - PALSY

U2 - 10.1038/pr.2015.20

DO - 10.1038/pr.2015.20

M3 - Article

C2 - 25665059

SN - 0031-3998

VL - 77

SP - 688

EP - 695

JO - Pediatric Research

JF - Pediatric Research

IS - 5

ER -

In preterm infants, ascending intrauterine infection is associated with lower cerebral tissue oxygen saturation and higher oxygen extraction

Samenvatting

Toegang tot document

Handle.net

Document onder embargo

Vingerafdruk

Citeer dit