Increased hepatic CD36 expression with age is associated with enhanced susceptibility to nonalcoholic fatty liver disease

Fareeba Sheedfar, Miranda M. Y. Sung, Marcela Aparicio-Vergara, Niels J. Kloosterhuis, Maria Eugenia Miquilena-Colina, Javier Vargas-Castrillon, Maria Febbraio, Rene L. Jacobs, Alain de Bruin, Manlio Vinciguerra, Carmelo Garcia-Monzon, Marten H. Hofker, Jason R. B. Dyck, Debby P. Y. Koonen*

*Corresponding author voor dit werk

OnderzoeksoutputAcademicpeer review

82 Citaten (Scopus)
367 Downloads (Pure)

Samenvatting

CD36 has been associated with obesity and diabetes in human liver diseases, however, its role in age-associated nonalcoholic fatty liver disease (NAFLD) is unknown. Therefore, liver biopsies were collected from individuals with histologically normal livers (n=30), and from patients diagnosed with simple steatosis (NAS; n=26). Patients were divided into two groups according to age and liver biopsy samples were immunostained for CD36. NAFLD parameters were examined in young (12-week) and middle-aged (52-week) C57BL/6J mice, some fed with chow-diet and some fed with low-fat (LFD; 10% kcal fat) or high-fat diet (HFD; 60% kcal fat) for 12-weeks. CD36 expression was positively associated with age in individuals with normal livers but not in NAS patients. However, CD36 was predominantly located at the plasma membrane of hepatocytes in aged NAS patients as compared to young. In chow-fed mice, aging, despite an increase in hepatic CD36 expression, was not associated with the development of NAFLD. However, middle-aged mice did exhibit the development of HFD-induced NAFLD, mediated by an increase of CD36 on the membrane. Enhanced CD36-mediated hepatic fat uptake may contribute to an accelerated progression of NAFLD in mice and humans. Therapies to prevent the increase in CD36 expression and/or CD36 from anchoring at the membrane may prevent the development of NAFLD.

Originele taal-2English
Pagina's (van-tot)281-295
Aantal pagina's15
TijdschriftAging-Us
Volume6
Nummer van het tijdschrift4
DOI's
StatusPublished - apr.-2014

Vingerafdruk

Duik in de onderzoeksthema's van 'Increased hepatic CD36 expression with age is associated with enhanced susceptibility to nonalcoholic fatty liver disease'. Samen vormen ze een unieke vingerafdruk.

Citeer dit