Infants with and without orofacial clefts: How their faces grow in 3D

Sander Brons

Onderzoeksoutput: Thesis defended at external organisation, UG (co)promotor, external graduate (EDEP)


Orofacial clefts are one of the most frequently diagnosed congenital craniofacial
malformations: about every 3 minutes somewhere in the world a child with cleft lip
and palate is born. The global incidence of cleft lip and/or palate is about 1 in 700 births
and the incidence of isolated cleft palate is about 1 in 1,000 births.1-4 Significant racial
differences in the birth prevalence of orofacial clefts exist, with the highest incidence in
Asian, intermediate in white, and lowest in black populations.2,5-8 In Europe the incidence
of orofacial clefts is about one per 500 – 700 of all births.2
Although there is a large number
of affected babies in the European Union as a whole, the numbers are relatively small on
a national level. In the Netherlands, the Dutch Association for Cleft Palate and Craniofacial
Anomalies (NVCSA) registers about 310-350 new unoperated patients with orofacial clefts
including unoperated adopted children per year.
Originele taal-2English
KwalificatieDoctor of Philosophy
Toekennende instantie
  • Radboud University Nijmegen
  • Kuijpers-Jagtman, Anne Marie, Supervisor
  • Bergé, S.J., Supervisor, Externe Persoon
  • Maal, Thomas J. J., Supervisor, Externe Persoon
Datum van toekenning3-dec-2019
Plaats van publicaties.l.
Gedrukte ISBN's978-94-6380-562-9
StatusPublished - 9-dec-2019
Extern gepubliceerdJa

Citeer dit