Infiltrating CTLs are bothered by HLA-E on tumors

Marloes J. M. Gooden, Thorbald van Hall*

*Bijbehorende auteur voor dit werk

    OnderzoeksoutputAcademicpeer review

    15 Citaten (Scopus)


    We recently described the upregulation of HLA-E in ovarian and cervical cancers. Instead of interacting with natural killer cells, HLA-E appeared to inhibit intratumoral cytotoxic T lymphocytes (CTL) via the receptor CD94/NKG2A. Strikingly, the survival benefit of intraepithelial infiltrating CTL was lost in those cancers with high HLA-E expression.

    Originele taal-2English
    Pagina's (van-tot)92-93
    Aantal pagina's2
    Nummer van het tijdschrift1
    StatusPublished - 2012

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