Inflammatory cells and airway defense against Aspergillus fumigatus

HF Kauffman*, JFC Tomee

*Bijbehorende auteur voor dit werk

    Onderzoeksoutputpeer review

    37 Citaten (Scopus)

    Samenvatting

    The authors offer a summary of the attack strategies of A. fumigatus and interactions with the airway defense system. The possible role of proteolytic enzymes from Aspergillus in the inflammatory response of the airways is also discussed. Evidence is given for the in vivo production of these proteolytic enzymes in patients with ABPA and aspergilloma. The authors also describe the role of epithelial attack by proteolytic enzymes, the induction of a first wave of chemokines, the succeeding Th2-type inflammatory response in atopic patients, and the role of eosinophils in the continuation of this inflammatory cycle. Possibilities for inhibition of this continuous cycle of inflammation, followed by the resolution of ABPA. are discussed.

    Originele taal-2English
    Pagina's (van-tot)619-+
    Aantal pagina's24
    TijdschriftImmunology and allergy clinics of north america
    Volume18
    Nummer van het tijdschrift3
    StatusPublished - aug.-1998

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