Objective: To assess the ability of Parkinson's patients to perform an inhalation manoeuvre correctly during an off period. Background: Due to the expected faster onset of effect compared to oral levodopa, administration of levodopa via a dry powder inhaler is an interesting alternative to oral levodopa in Parkinson's patients in an off period. During an off period, the motor function is impaired and the patient is suffering from symptoms like bradykinesia, tremor and rigidity. Little is known about the ability to use dry powder inhalers during an off period. We studied the inspiratory flow manoeuvre performed by Parkinson's patients in an off period. Methods: After informed consent was obtained, 13 Parkinson's patients in an off period simulated inhalation manoeuvres through a testinhaler, with 3 different resistances to air flow. These resistances to air flow are considered medium/high to high, according to the ERS/ISAM task force consensus statement. With the obtained flow curves, we calculated various inhalation parameters. Results: The mean PIF and its ranges were found to increase with decreasing resistance to air flow. The average inhaled volume was > 2 L, for all three resistances to air flow. The total inhalation time and time to PIF were found to decrease with decreasing resistance to air flow. Twelve out of thirteen patients were able to hold their breath for at least 5 seconds after inhalation. Nine of them were able to extend the breath hold time to 10 seconds. Conclusions: Most Parkinson's patients demonstrated the ability to perform an inhalation manoeuvre that is expected to be sufficient for the successful use of a dry powder inhaler by this particular patient group.
|Tijdschrift||European Respiratory Journal|
|Nummer van het tijdschrift||Supl. 59|
|Status||Published - 1-sep.-2015|