TY - JOUR
T1 - Innovative and rapid antimicrobial susceptibility testing systems
AU - van Belkum, Alex
AU - Burnham, Carey-Ann D.
AU - Rossen, John W. A.
AU - Mallard, Frederic
AU - Rochas, Olivier
AU - Dunne, William Michael
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Antimicrobial resistance (AMR) is a major threat to human health worldwide, and the rapid detection and quantification of resistance, combined with antimicrobial stewardship, are key interventions to combat the spread and emergence of AMR. Antimicrobial susceptibility testing (AST) systems are the collective set of diagnostic processes that facilitate the phenotypic and genotypic assessment of AMR and antibiotic susceptibility. Over the past 30 years, only a few high-throughput AST methods have been developed and widely implemented. By contrast, several studies have established proof of principle for various innovative AST methods, including both molecular-based and genome-based methods, which await clinical trials and regulatory review. In this Review, we discuss the current state of AST systems in the broadest technical, translational and implementation-related scope.
AB - Antimicrobial resistance (AMR) is a major threat to human health worldwide, and the rapid detection and quantification of resistance, combined with antimicrobial stewardship, are key interventions to combat the spread and emergence of AMR. Antimicrobial susceptibility testing (AST) systems are the collective set of diagnostic processes that facilitate the phenotypic and genotypic assessment of AMR and antibiotic susceptibility. Over the past 30 years, only a few high-throughput AST methods have been developed and widely implemented. By contrast, several studies have established proof of principle for various innovative AST methods, including both molecular-based and genome-based methods, which await clinical trials and regulatory review. In this Review, we discuss the current state of AST systems in the broadest technical, translational and implementation-related scope.
KW - POSITIVE BLOOD CULTURES
KW - ANTIBIOTIC-RESISTANCE
KW - MYCOBACTERIUM-TUBERCULOSIS
KW - CLINICAL MICROBIOLOGY
KW - DIARRHEAL DISEASE
KW - IDENTIFICATION
KW - PCR
KW - DIAGNOSTICS
KW - ASSAY
KW - TOOL
U2 - 10.1038/s41579-020-0327-x
DO - 10.1038/s41579-020-0327-x
M3 - Review article
C2 - 32055026
SN - 1740-1526
SP - 299
EP - 311
JO - Nature Reviews Microbiology
JF - Nature Reviews Microbiology
IS - 5
ER -