Intermuscular coherence as biomarker for pallidal deep brain stimulation efficacy in dystonia

E Doldersum; J C van Zijl; M Beudel; H Eggink; R Brandsma; D Piña-Fuentes; M E van Egmond; D L M Oterdoom; J M C van Dijk; J W J Elting; M A J Tijssen

doi:10.1016/j.clinph.2019.04.717

Intermuscular coherence as biomarker for pallidal deep brain stimulation efficacy in dystonia

E Doldersum, J C van Zijl, M Beudel, H Eggink, R Brandsma, D Piña-Fuentes, M E van Egmond, D L M Oterdoom, J M C van Dijk, J W J Elting, M A J Tijssen

Movement Disorder (MD)

Onderzoeksoutput › Academic › peer review

8 Citaten (Scopus)

Samenvatting

Objective: Finding a non-invasive biomarker for Globus Pallidus interna Deep Brain Stimulation (GPiDBS) efficacy. Dystonia heterogeneity leads to a wide variety of clinical response to GPi-DBS, making it hard to predict GPi-DBS efficacy for individual patients.

Methods: EEG-EMG recordings of twelve dystonia patients who received bilateral GPi-DBS took place pre-and 1 year post-surgery ON and OFF stimulation, during a rest, pinch, and flexion task. Dystonia severity was assessed using the BFMDRS and TWSTRS (pre-and post-surgery ON stimulation). Intermuscular coherence (IMC) and motorcortex corticomuscular coherence (CMC) were calculated. Low frequency (4-12 Hz) and beta band (13-30 Hz) peak coherences were studied.

Results: Dystonia severity improved after 1 year GPi-DBS therapy (BFMDRS: 30%, median 7.8 (IQR 3-10), TWSTRS: 22%, median 6.8 (IQR 4-9)). 86% of IMC were above the 95% confidence limit. The highest IMC peak decreased significantly with GPi-DBS in the low frequency and beta band. Low frequency and beta band IMC correlated partly with dystonia severity and severity improvement. CMC generally were below the 95% confidence limit.

Conclusions: Peak low frequency IMC functioned as biomarker for GPi-DBS efficacy, and partly correlated with dystonia severity. Significance: IMC can function as biomarker. Confirmation in a larger study is needed for use in clinical practice. (C) 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights

Originele taal-2	English
Pagina's (van-tot)	1351-1357
Aantal pagina's	7
Tijdschrift	Clinical Neurophysiology
Volume	130
Nummer van het tijdschrift	8
Vroegere onlinedatum	2019
DOI's	https://doi.org/10.1016/j.clinph.2019.04.717
Status	Published - aug-2019

Toegang tot document

10.1016/j.clinph.2019.04.717

Document onder embargo

Intermuscular coherence as biomarker for pallidal deep brain stimulation efficacy in dystonia
Final publisher's version, 241 KB
Kopie aanvragen

Citeer dit

Doldersum, E., van Zijl, J. C., Beudel, M., Eggink, H., Brandsma, R., Piña-Fuentes, D., van Egmond, M. E., Oterdoom, D. L. M., van Dijk, J. M. C., Elting, J. W. J., & Tijssen, M. A. J. (2019). Intermuscular coherence as biomarker for pallidal deep brain stimulation efficacy in dystonia. Clinical Neurophysiology, 130(8), 1351-1357. https://doi.org/10.1016/j.clinph.2019.04.717

@article{ce26ce56e01443359e40746ce085245b,

title = "Intermuscular coherence as biomarker for pallidal deep brain stimulation efficacy in dystonia",

abstract = "Objective: Finding a non-invasive biomarker for Globus Pallidus interna Deep Brain Stimulation (GPiDBS) efficacy. Dystonia heterogeneity leads to a wide variety of clinical response to GPi-DBS, making it hard to predict GPi-DBS efficacy for individual patients.Methods: EEG-EMG recordings of twelve dystonia patients who received bilateral GPi-DBS took place pre-and 1 year post-surgery ON and OFF stimulation, during a rest, pinch, and flexion task. Dystonia severity was assessed using the BFMDRS and TWSTRS (pre-and post-surgery ON stimulation). Intermuscular coherence (IMC) and motorcortex corticomuscular coherence (CMC) were calculated. Low frequency (4-12 Hz) and beta band (13-30 Hz) peak coherences were studied.Results: Dystonia severity improved after 1 year GPi-DBS therapy (BFMDRS: 30%, median 7.8 (IQR 3-10), TWSTRS: 22%, median 6.8 (IQR 4-9)). 86% of IMC were above the 95% confidence limit. The highest IMC peak decreased significantly with GPi-DBS in the low frequency and beta band. Low frequency and beta band IMC correlated partly with dystonia severity and severity improvement. CMC generally were below the 95% confidence limit.Conclusions: Peak low frequency IMC functioned as biomarker for GPi-DBS efficacy, and partly correlated with dystonia severity. Significance: IMC can function as biomarker. Confirmation in a larger study is needed for use in clinical practice. (C) 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights",

keywords = "Dystonia, Deep brain stimulation, Biomarker, Intermuscular coherence, INTERNAL GLOBUS-PALLIDUS, LOCAL-FIELD POTENTIALS, PARKINSONS-DISEASE, MUSCLE-ACTIVITY, EMG COHERENCE, MOVEMENT, OSCILLATIONS, SYNCHRONIZATION, CONNECTIVITY, PATTERNS",

author = "E Doldersum and {van Zijl}, {J C} and M Beudel and H Eggink and R Brandsma and D Pi{\~n}a-Fuentes and {van Egmond}, {M E} and Oterdoom, {D L M} and {van Dijk}, {J M C} and Elting, {J W J} and Tijssen, {M A J}",

year = "2019",

month = aug,

doi = "10.1016/j.clinph.2019.04.717",

language = "English",

volume = "130",

pages = "1351--1357",

journal = "Clinical Neurophysiology",

issn = "1388-2457",

publisher = "ELSEVIER IRELAND LTD",

number = "8",

}

Intermuscular coherence as biomarker for pallidal deep brain stimulation efficacy in dystonia. / Doldersum, E; van Zijl, J C; Beudel, M; Eggink, H; Brandsma, R; Piña-Fuentes, D ; van Egmond, M E ; Oterdoom, D L M ; van Dijk, J M C ; Elting, J W J ; Tijssen, M A J.

In: Clinical Neurophysiology, Vol. 130, Nr. 8, 08.2019, blz. 1351-1357.

Onderzoeksoutput › Academic › peer review

TY - JOUR

T1 - Intermuscular coherence as biomarker for pallidal deep brain stimulation efficacy in dystonia

AU - Doldersum, E

AU - van Zijl, J C

AU - Beudel, M

AU - Eggink, H

AU - Brandsma, R

AU - Piña-Fuentes, D

AU - van Egmond, M E

AU - Oterdoom, D L M

AU - van Dijk, J M C

AU - Elting, J W J

AU - Tijssen, M A J

PY - 2019/8

Y1 - 2019/8

N2 - Objective: Finding a non-invasive biomarker for Globus Pallidus interna Deep Brain Stimulation (GPiDBS) efficacy. Dystonia heterogeneity leads to a wide variety of clinical response to GPi-DBS, making it hard to predict GPi-DBS efficacy for individual patients.Methods: EEG-EMG recordings of twelve dystonia patients who received bilateral GPi-DBS took place pre-and 1 year post-surgery ON and OFF stimulation, during a rest, pinch, and flexion task. Dystonia severity was assessed using the BFMDRS and TWSTRS (pre-and post-surgery ON stimulation). Intermuscular coherence (IMC) and motorcortex corticomuscular coherence (CMC) were calculated. Low frequency (4-12 Hz) and beta band (13-30 Hz) peak coherences were studied.Results: Dystonia severity improved after 1 year GPi-DBS therapy (BFMDRS: 30%, median 7.8 (IQR 3-10), TWSTRS: 22%, median 6.8 (IQR 4-9)). 86% of IMC were above the 95% confidence limit. The highest IMC peak decreased significantly with GPi-DBS in the low frequency and beta band. Low frequency and beta band IMC correlated partly with dystonia severity and severity improvement. CMC generally were below the 95% confidence limit.Conclusions: Peak low frequency IMC functioned as biomarker for GPi-DBS efficacy, and partly correlated with dystonia severity. Significance: IMC can function as biomarker. Confirmation in a larger study is needed for use in clinical practice. (C) 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights

AB - Objective: Finding a non-invasive biomarker for Globus Pallidus interna Deep Brain Stimulation (GPiDBS) efficacy. Dystonia heterogeneity leads to a wide variety of clinical response to GPi-DBS, making it hard to predict GPi-DBS efficacy for individual patients.Methods: EEG-EMG recordings of twelve dystonia patients who received bilateral GPi-DBS took place pre-and 1 year post-surgery ON and OFF stimulation, during a rest, pinch, and flexion task. Dystonia severity was assessed using the BFMDRS and TWSTRS (pre-and post-surgery ON stimulation). Intermuscular coherence (IMC) and motorcortex corticomuscular coherence (CMC) were calculated. Low frequency (4-12 Hz) and beta band (13-30 Hz) peak coherences were studied.Results: Dystonia severity improved after 1 year GPi-DBS therapy (BFMDRS: 30%, median 7.8 (IQR 3-10), TWSTRS: 22%, median 6.8 (IQR 4-9)). 86% of IMC were above the 95% confidence limit. The highest IMC peak decreased significantly with GPi-DBS in the low frequency and beta band. Low frequency and beta band IMC correlated partly with dystonia severity and severity improvement. CMC generally were below the 95% confidence limit.Conclusions: Peak low frequency IMC functioned as biomarker for GPi-DBS efficacy, and partly correlated with dystonia severity. Significance: IMC can function as biomarker. Confirmation in a larger study is needed for use in clinical practice. (C) 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights

KW - Dystonia

KW - Deep brain stimulation

KW - Biomarker

KW - Intermuscular coherence

KW - INTERNAL GLOBUS-PALLIDUS

KW - LOCAL-FIELD POTENTIALS

KW - PARKINSONS-DISEASE

KW - MUSCLE-ACTIVITY

KW - EMG COHERENCE

KW - MOVEMENT

KW - OSCILLATIONS

KW - SYNCHRONIZATION

KW - CONNECTIVITY

KW - PATTERNS

U2 - 10.1016/j.clinph.2019.04.717

DO - 10.1016/j.clinph.2019.04.717

M3 - Article

C2 - 31207566

VL - 130

SP - 1351

EP - 1357

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

SN - 1388-2457

IS - 8

ER -