Intermuscular coherence as biomarker for pallidal deep brain stimulation efficacy in dystonia

E Doldersum; J C van Zijl; M Beudel; H Eggink; R Brandsma; D Piña-Fuentes; M E van Egmond; D L M Oterdoom; J M C van Dijk; J W J Elting; M A J Tijssen

doi:10.1016/j.clinph.2019.04.717

Intermuscular coherence as biomarker for pallidal deep brain stimulation efficacy in dystonia

E Doldersum, J C van Zijl, M Beudel, H Eggink, R Brandsma, D Piña-Fuentes, M E van Egmond, D L M Oterdoom, J M C van Dijk, J W J Elting, M A J Tijssen

Biology-Related, Artificial, and Interventional Neuroscience (BRAIN)

Onderzoeksoutput: Article › Academic › peer review

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Objective: Finding a non-invasive biomarker for Globus Pallidus interna Deep Brain Stimulation (GPiDBS) efficacy. Dystonia heterogeneity leads to a wide variety of clinical response to GPi-DBS, making it hard to predict GPi-DBS efficacy for individual patients.

Methods: EEG-EMG recordings of twelve dystonia patients who received bilateral GPi-DBS took place pre-and 1 year post-surgery ON and OFF stimulation, during a rest, pinch, and flexion task. Dystonia severity was assessed using the BFMDRS and TWSTRS (pre-and post-surgery ON stimulation). Intermuscular coherence (IMC) and motorcortex corticomuscular coherence (CMC) were calculated. Low frequency (4-12 Hz) and beta band (13-30 Hz) peak coherences were studied.

Results: Dystonia severity improved after 1 year GPi-DBS therapy (BFMDRS: 30%, median 7.8 (IQR 3-10), TWSTRS: 22%, median 6.8 (IQR 4-9)). 86% of IMC were above the 95% confidence limit. The highest IMC peak decreased significantly with GPi-DBS in the low frequency and beta band. Low frequency and beta band IMC correlated partly with dystonia severity and severity improvement. CMC generally were below the 95% confidence limit.

Conclusions: Peak low frequency IMC functioned as biomarker for GPi-DBS efficacy, and partly correlated with dystonia severity. Significance: IMC can function as biomarker. Confirmation in a larger study is needed for use in clinical practice. (C) 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights

Originele taal-2	English
Pagina's (van-tot)	1351-1357
Aantal pagina's	7
Tijdschrift	Clinical Neurophysiology
Volume	130
Nummer van het tijdschrift	8
Vroegere onlinedatum	2019
DOI's	https://doi.org/10.1016/j.clinph.2019.04.717
Status	Published - aug.-2019

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Intermuscular coherence as biomarker for pallidal deep brain stimulation efficacy in dystoniaFinal publisher's version, 241 KBLicentie: Taverne

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Doldersum, E., van Zijl, J. C., Beudel, M., Eggink, H., Brandsma, R., Piña-Fuentes, D., van Egmond, M. E., Oterdoom, D. L. M., van Dijk, J. M. C., Elting, J. W. J., & Tijssen, M. A. J. (2019). Intermuscular coherence as biomarker for pallidal deep brain stimulation efficacy in dystonia. Clinical Neurophysiology, 130(8), 1351-1357. https://doi.org/10.1016/j.clinph.2019.04.717

@article{ce26ce56e01443359e40746ce085245b,

title = "Intermuscular coherence as biomarker for pallidal deep brain stimulation efficacy in dystonia",

abstract = "Objective: Finding a non-invasive biomarker for Globus Pallidus interna Deep Brain Stimulation (GPiDBS) efficacy. Dystonia heterogeneity leads to a wide variety of clinical response to GPi-DBS, making it hard to predict GPi-DBS efficacy for individual patients.Methods: EEG-EMG recordings of twelve dystonia patients who received bilateral GPi-DBS took place pre-and 1 year post-surgery ON and OFF stimulation, during a rest, pinch, and flexion task. Dystonia severity was assessed using the BFMDRS and TWSTRS (pre-and post-surgery ON stimulation). Intermuscular coherence (IMC) and motorcortex corticomuscular coherence (CMC) were calculated. Low frequency (4-12 Hz) and beta band (13-30 Hz) peak coherences were studied.Results: Dystonia severity improved after 1 year GPi-DBS therapy (BFMDRS: 30%, median 7.8 (IQR 3-10), TWSTRS: 22%, median 6.8 (IQR 4-9)). 86% of IMC were above the 95% confidence limit. The highest IMC peak decreased significantly with GPi-DBS in the low frequency and beta band. Low frequency and beta band IMC correlated partly with dystonia severity and severity improvement. CMC generally were below the 95% confidence limit.Conclusions: Peak low frequency IMC functioned as biomarker for GPi-DBS efficacy, and partly correlated with dystonia severity. Significance: IMC can function as biomarker. Confirmation in a larger study is needed for use in clinical practice. (C) 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights",

keywords = "Dystonia, Deep brain stimulation, Biomarker, Intermuscular coherence, INTERNAL GLOBUS-PALLIDUS, LOCAL-FIELD POTENTIALS, PARKINSONS-DISEASE, MUSCLE-ACTIVITY, EMG COHERENCE, MOVEMENT, OSCILLATIONS, SYNCHRONIZATION, CONNECTIVITY, PATTERNS",

author = "E Doldersum and {van Zijl}, {J C} and M Beudel and H Eggink and R Brandsma and D Pi{\~n}a-Fuentes and {van Egmond}, {M E} and Oterdoom, {D L M} and {van Dijk}, {J M C} and Elting, {J W J} and Tijssen, {M A J}",

year = "2019",

month = aug,

doi = "10.1016/j.clinph.2019.04.717",

language = "English",

volume = "130",

pages = "1351--1357",

journal = "Clinical Neurophysiology",

issn = "1388-2457",

publisher = "ELSEVIER IRELAND LTD",

number = "8",

}

TY - JOUR

T1 - Intermuscular coherence as biomarker for pallidal deep brain stimulation efficacy in dystonia

AU - Doldersum, E

AU - van Zijl, J C

AU - Beudel, M

AU - Eggink, H

AU - Brandsma, R

AU - Piña-Fuentes, D

AU - van Egmond, M E

AU - Oterdoom, D L M

AU - van Dijk, J M C

AU - Elting, J W J

AU - Tijssen, M A J

PY - 2019/8

Y1 - 2019/8

N2 - Objective: Finding a non-invasive biomarker for Globus Pallidus interna Deep Brain Stimulation (GPiDBS) efficacy. Dystonia heterogeneity leads to a wide variety of clinical response to GPi-DBS, making it hard to predict GPi-DBS efficacy for individual patients.Methods: EEG-EMG recordings of twelve dystonia patients who received bilateral GPi-DBS took place pre-and 1 year post-surgery ON and OFF stimulation, during a rest, pinch, and flexion task. Dystonia severity was assessed using the BFMDRS and TWSTRS (pre-and post-surgery ON stimulation). Intermuscular coherence (IMC) and motorcortex corticomuscular coherence (CMC) were calculated. Low frequency (4-12 Hz) and beta band (13-30 Hz) peak coherences were studied.Results: Dystonia severity improved after 1 year GPi-DBS therapy (BFMDRS: 30%, median 7.8 (IQR 3-10), TWSTRS: 22%, median 6.8 (IQR 4-9)). 86% of IMC were above the 95% confidence limit. The highest IMC peak decreased significantly with GPi-DBS in the low frequency and beta band. Low frequency and beta band IMC correlated partly with dystonia severity and severity improvement. CMC generally were below the 95% confidence limit.Conclusions: Peak low frequency IMC functioned as biomarker for GPi-DBS efficacy, and partly correlated with dystonia severity. Significance: IMC can function as biomarker. Confirmation in a larger study is needed for use in clinical practice. (C) 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights

AB - Objective: Finding a non-invasive biomarker for Globus Pallidus interna Deep Brain Stimulation (GPiDBS) efficacy. Dystonia heterogeneity leads to a wide variety of clinical response to GPi-DBS, making it hard to predict GPi-DBS efficacy for individual patients.Methods: EEG-EMG recordings of twelve dystonia patients who received bilateral GPi-DBS took place pre-and 1 year post-surgery ON and OFF stimulation, during a rest, pinch, and flexion task. Dystonia severity was assessed using the BFMDRS and TWSTRS (pre-and post-surgery ON stimulation). Intermuscular coherence (IMC) and motorcortex corticomuscular coherence (CMC) were calculated. Low frequency (4-12 Hz) and beta band (13-30 Hz) peak coherences were studied.Results: Dystonia severity improved after 1 year GPi-DBS therapy (BFMDRS: 30%, median 7.8 (IQR 3-10), TWSTRS: 22%, median 6.8 (IQR 4-9)). 86% of IMC were above the 95% confidence limit. The highest IMC peak decreased significantly with GPi-DBS in the low frequency and beta band. Low frequency and beta band IMC correlated partly with dystonia severity and severity improvement. CMC generally were below the 95% confidence limit.Conclusions: Peak low frequency IMC functioned as biomarker for GPi-DBS efficacy, and partly correlated with dystonia severity. Significance: IMC can function as biomarker. Confirmation in a larger study is needed for use in clinical practice. (C) 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights

KW - Dystonia

KW - Deep brain stimulation

KW - Biomarker

KW - Intermuscular coherence

KW - INTERNAL GLOBUS-PALLIDUS

KW - LOCAL-FIELD POTENTIALS

KW - PARKINSONS-DISEASE

KW - MUSCLE-ACTIVITY

KW - EMG COHERENCE

KW - MOVEMENT

KW - OSCILLATIONS

KW - SYNCHRONIZATION

KW - CONNECTIVITY

KW - PATTERNS

U2 - 10.1016/j.clinph.2019.04.717

DO - 10.1016/j.clinph.2019.04.717

M3 - Article

C2 - 31207566

SN - 1388-2457

VL - 130

SP - 1351

EP - 1357

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

IS - 8

ER -

Intermuscular coherence as biomarker for pallidal deep brain stimulation efficacy in dystonia

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