International consensus on the diagnosis and management of dumping syndrome

Emidio Scarpellini, Joris Arts, George Karamanolis, Anna Laurenius, Walter Siquini, Hidekazu Suzuki, Andrew Ukleja, Andre Van Beek, Tim Vanuytsel, Serhat Bor, Eugene Ceppa, Carlo Di Lorenzo, Marloes Emous, Heinz Hammer, Per Hellstrom, Martine Laville, Lars Lundell, Ad Masclee, Patrick Ritz, Jan Tack*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

43 Citaten (Scopus)
41 Downloads (Pure)

Samenvatting

Dumping syndrome is a common but underdiagnosed complication of gastric and oesophageal surgery. We initiated a Delphi consensus process with international multidisciplinary experts. We defined the scope, proposed statements and searched electronic databases to survey the literature. Eighteen experts participated in the literature summary and voting process evaluating 62 statements. We evaluated the quality of evidence using grading of recommendations assessment, development and evaluation (GRADE) criteria. Consensus (defined as >80% agreement) was reached for 33 of 62 statements, including the definition and symptom profile of dumping syndrome and its effect on quality of life. The panel agreed on the pathophysiological relevance of rapid passage of nutrients to the small bowel, on the role of decreased gastric volume capacity and release of glucagon-like peptide 1. Symptom recognition is crucial, and the modified oral glucose tolerance test, but not gastric emptying testing, is useful for diagnosis. An increase in haematocrit >3% or in pulse rate >10 bpm 30 min after the start of the glucose intake are diagnostic of early dumping syndrome, and a nadir hypoglycaemia level <50 mg/dl is diagnostic of late dumping syndrome. Dietary adjustment is the agreed first treatment step; acarbose is effective for late dumping syndrome symptoms and somatostatin analogues are preferred for patients who do not respond to diet adjustments and acarbose.

Originele taal-2English
Pagina's (van-tot)448-466
Aantal pagina's19
TijdschriftNature reviews endocrinology
Volume16
Nummer van het tijdschrift8
DOI's
StatusPublished - 1-aug-2020

Citeer dit