@inproceedings{624086c5409644eeac739ea1e69acf85,
title = "Investigating the Molecular Basis of Major Depressive Disorder Etiology",
abstract = "Genes play a major role in behavioral adaptation to challenging environmental stimuli, but the complexity of their contribution remains unclear. There is growing evidence linking disease phenotypes with genes on the one hand, and the genesis of stress-related disorders like major depression, as a result of exposure to stressful environmental pathogens on the other. Here we illustrate the convergent role of monoaminergic genes in regulating the underlying biological mechanisms of stress and the emotions. By reviewing data that support a role of monoaminergic and other related genes in environmental adaptation, we conclude by advocating the use of convergent approaches in examining the genetic modulation of disease phenotypes.",
keywords = "stress, genes, monoamines, MDD, convergent, CATECHOL-O-METHYLTRANSFERASE, CORTICOTROPIN-RELEASING HORMONE, NATIONAL COMORBIDITY SURVEY, PITUITARY-ADRENAL AXIS, STRESSFUL LIFE EVENTS, GENE-ENVIRONMENT INTERACTION, ANXIETY-LIKE BEHAVIOR, SECRETION IN-VITRO, SEROTONIN TRANSPORTER, MONOAMINE-OXIDASE",
author = "Mbemba Jabbi and Jaalp Korf and Johan Ormel and Kema, {Ido P.} and {den Boer}, {Johan A.}",
year = "2008",
doi = "10.1196/annals.1410.018",
language = "English",
isbn = "978-1-57331-692-7",
series = "Annals of the New York Academy of Sciences",
publisher = "Blackwell Publishing",
pages = "42--56",
editor = "R Kvetnansky and G Aguilera and D Goldstein and D Jezova and O Krizanova and EL Sabban and K Pacak",
booktitle = "STRESS, NEUROTRANSMITTERS, AND HORMONES: NEUROENDOCRINE AND GENETIC MECHANISMS",
note = "9th Symposium on Catecholamines and Other Neurotransmitters in Stress ; Conference date: 16-06-2007 Through 21-06-2007",
}