Involvement of capsaicin-sensitive nerves in regulation of insulin secretion and glucose tolerance in conscious mice

Sven Karlsson, Anton J.W. Scheurink, Anton B. Steffens, Bo Ahrén

OnderzoeksoutputAcademicpeer review

55 Citaten (Scopus)


The impact of sensory nerves in glucose-stimulated insulin secretion and glucose tolerance was investigated in conscious mice treated neonatally with either capsaicin (Cap) or vehicle (Veh). At 10-12 wk after Cap, both the early (1 min) insulin secretory response to intravenous glucose (2.8 mmol/kg) (by 67%) and glucose elimination were potentiated (P <0.05). In contrast, basal insulin, glucagon, and glucose were not affected by Cap. Plasma norepinephrine and epinephrine levels did not differ between Cap- and Veh-treated animals, whereas the increase in plasma insulin levels normally induced by alpha-adrenoceptor blockade by phentolamine was absent after Cap treatment. In isolated islets, the insulin secretory response to glucose (20 mmol/l), carbachol (0.1 mmol/l), or phentolamine (0.5 mmol/l) was not affected after Cap. It is concluded that sensory denervation by Cap results in increased glucose tolerance, which is in part because of a potentiated early insulin response to glucose. This potentiation does not seem secondary to altered plasma catecholamine levels or to altered islet secretory capacity. The results suggest rather that Cap-sensitive nerves, by a local effector function and/or as the afferent loop of a neural reflex, exert inhibitory influences on insulin secretion.

Originele taal-2English
Pagina's (van-tot)R1071-R1077
Aantal pagina's7
TijdschriftThe American Journal of Physiology - Regulatory, Integrative and Comparative Physiology
Nummer van het tijdschrift4
StatusPublished - okt-1994

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