In this study, we analyze in-depth interviews conducted with 26 Dutch third-graders as well as interviews with one of each child's parents. The children attended one of six schools, each with a relatively large population of families with a low socioeconomic status, where home-based literacy assignments aimed at increasing children's enjoyment of reading were distributed for a duration of 3 years. The aim of this study is to gain knowledge of distinctive interaction characteristics of child-parent dyads regarding at-home literacy, to learn how these characteristics can help educational professionals and researchers answer to the needs of children and parents when designing and distributing at-home reading assignments. Based on the attitudes towards reading and the skillset of child and parent(s), we distinguished three reader-profiles: (1) Autonomously motivated readers, (2) Incompatible readers, and (3) Generational non-readers. The practical implications of our research are that, to be appealing, at-home reading assignments should be differentiated, nonrepetitive, and concrete, complete, and structured. Prerequisite implications are that both children and parents value regular positive feedback on their at-home literacy activities and that, in approaching parents, it appears to be advisable to take them for what they are: parents, not substitute teachers.